Document Detail

Central obesity and hypertension: the role of plasma endothelin.
MedLine Citation:
PMID:  8972889     Owner:  NLM     Status:  MEDLINE    
Hypertension and central obesity are two conditions closely linked, but the mechanisms responsible for obesity-associated hypertension are still unclear. In the last few years, several studies addressed the role of endothelin-1 (ET-1) in the development and maintenance of hypertension. This study was designed to evaluate plasma ET-1 in normotensive and hypertensive central obese subjects compared with a lean healthy group. Our final goal was to analyze the relationship between plasma ET-1, blood pressure, and left ventricular structure and function in central obese subjects (both normotensives and hypertensives). ET-levels have been assessed by the radioimmunoassay method in 20 lean normotensives and in 57 central obese subjects; 30 of them were hypertensives and 27 of them were normotensives. Twenty-four-hour mean blood pressure (MBP/24 h) by noninvasive ambulatory blood pressure monitoring, left ventricular mass/ height (LVM/H), and left ventricular ejection fraction (LVEF) by echocardiography and peak filling rate (PFR) by radionuclide study were also measured. ET levels were significantly (P < .05) higher in obese hypertensives and obese normotensives than in lean normotensives. In addition, ET levels were significantly (P < .05) higher in obese hypertensives than in obese normotensives. ET were directly related to LVM/ H (r = 0.86; P < .001) and MBP/24 h (r = 0.48; P < .009) but only in obese hypertensives. Multiple regression analysis indicated that ET-1 plasma levels remain an independent predictor of MBP/ 24 h and LVM/H also when age was included in the analysis. These data suggest that obesity-associated hypertension is characterized by an endothelial dysfunction that may contribute to the higher cardiovascular risk detectable in these patients.
G Parrinello; R Scaglione; A Pinto; S Corrao; M Cecala; G Di Silvestre; P Amato; A Licata; G Licata
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  9     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-04-08     Completed Date:  1997-04-08     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1186-91     Citation Subset:  IM    
Department of Internal Medicine, University of Palermo, Italy.
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MeSH Terms
Blood Pressure Monitoring, Ambulatory
Body Constitution
Body Height
Body Mass Index
Endothelin-1 / blood*
Heart Rate
Hypertension / blood,  complications*,  physiopathology
Obesity, Morbid / blood,  complications*,  physiopathology
Radionuclide Angiography
Regression Analysis
Stroke Volume
Ventricular Dysfunction, Left / complications,  diagnosis,  physiopathology
Reg. No./Substance:

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