| Central obesity and the aging brain. | |
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MedLine Citation:
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PMID: 16216937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Central adiposity as an indicator of visceral fat is linked to vascular and metabolic factors that in turn are related to cognitive decline and dementia. OBJECTIVE: To determine whether larger waist-hip ratio (WHR) is associated with structural brain changes that underlie cognitive decline and dementia. DESIGN: Cross-sectional analysis of an epidemiologic cohort study of cognitive and functional decline (Sacramento Area Latino Study on Aging). SETTING: California Central Valley. PARTICIPANTS: A total of 112 individuals selected from an ongoing cohort study of 1789 older Latino individuals. Baseline anthropomorphic measures (WHR) and measurements of fasting blood glucose, cholesterol, and insulin levels and blood pressure were obtained. MAIN OUTCOME MEASURES: Baseline magnetic resonance images were analyzed quantitatively to determine the hippocampal volumes in the right and left hemispheres and rated for the percentage of white matter hyperintensities. RESULTS: Greater WHR (P = .02) and older age (P<.001) were negatively related to hippocampal volumes. The WHR and age were positively related to white matter hyperintensities (P = .02 and P = .001, respectively). A 1-SD increase in WHR was associated with a 0.2-SD decrease in hippocampal volume and a 27% increase in white matter hyperintensities. These relationships were not affected by adjustment for body mass index, total cholesterol, fasting blood glucose, and insulin levels or systolic blood pressure in the models. CONCLUSION: A larger WHR may be related to neurodegenerative, vascular, or metabolic processes that affect brain structures underlying cognitive decline and dementia. |
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Authors:
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William Jagust; Danielle Harvey; Dan Mungas; Mary Haan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of neurology Volume: 62 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-11 Completed Date: 2005-11-15 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1545-8 Citation Subset: AIM; IM |
Affiliation:
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School of Public Health and Helen Wills Neuroscience Institute, University of California at Berkeley, 94720, USA. jagust@berkeley.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging* Brain / pathology* Brain Diseases / etiology* Cross-Sectional Studies Humans Magnetic Resonance Imaging Middle Aged Obesity / complications* Waist-Hip Ratio / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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AG10220/AG/NIA NIH HHS; AG12975/AG/NIA NIH HHS; DK60753/DK/NIDDK NIH HHS; R01 AG012975-03/AG/NIA NIH HHS; R01 AG012975-03S1/AG/NIA NIH HHS; R01 AG012975-04/AG/NIA NIH HHS; R01 AG012975-05/AG/NIA NIH HHS; R01 AG012975-06/AG/NIA NIH HHS; R01 AG012975-06S1/AG/NIA NIH HHS; R01 AG012975-07A2/AG/NIA NIH HHS; R01 AG012975-08/AG/NIA NIH HHS; R01 AG012975-09/AG/NIA NIH HHS; R01 AG012975-10/AG/NIA NIH HHS; R01 AG012975-11/AG/NIA NIH HHS; R01 AG012975-12A2/AG/NIA NIH HHS; R01 AG012975-13/AG/NIA NIH HHS; R01 AG012975-14/AG/NIA NIH HHS; R01 DK060753-01/DK/NIDDK NIH HHS; R01 DK060753-02/DK/NIDDK NIH HHS; R01 DK060753-03/DK/NIDDK NIH HHS; R03 AG033751-01A2/AG/NIA NIH HHS |
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