Document Detail

Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks.
MedLine Citation:
PMID:  17936900     Owner:  NLM     Status:  MEDLINE    
Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0, 4.16, 8.32 or 16.6nmol NPFF, and feed and water intake were quantified. Feed intake was linearly decreased as NPFF dose increased, and this effect decayed over time and was not significant by 120min post-injection. Water intake was not affected by ICV NPFF. In a second exp, we observed that naloxone completely reversed the NPFF-induced decrease in feed intake. The amount of time a visible marker took to travel through the total length of the alimentary canal linearly increased as NPFF dose increased. We measured neuronal activation in the lateral hypothalamus (LH), paraventricular nucleus (PVN) dorsomedial nucleus (DMN) and ventromedial hypothalamus (VMN) of the hypothalamus, and nucleus dorsomedialis posterior thalami (DMP) of the thalamus. The DMN, DMP, PVN and VMH were all activated by ICV NPFF while the LH was not affected. Finally, we determined that the anorexigenic effect of ICV NPFF is primarily behavior specific, since behaviors unrelated to ingestion were not increased the same duration of time as was consumatory pecking. We conclude that NPFF causes anorexigenic effects in chicks that are primarily behavior specific.
Mark A Cline; Wint Nandar; J Orion Rogers
Publication Detail:
Type:  Journal Article     Date:  2007-10-22
Journal Detail:
Title:  Neuropeptides     Volume:  41     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  433-9     Citation Subset:  IM    
Department of Biology, Radford University, P.O. Box 6931, Radford, VA 24142, USA.
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MeSH Terms
Anorexia / chemically induced*
Appetite Regulation / drug effects
Drinking / drug effects
Eating / drug effects*
Feeding Behavior / drug effects
Hypothalamus / chemistry*,  drug effects
Narcotic Antagonists / pharmacology
Neuropeptides / pharmacology
Oligopeptides / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Narcotic Antagonists; 0/Neuropeptides; 0/Oligopeptides; 99566-27-5/phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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