Document Detail


Central neurogenic mechanisms of migraine.
MedLine Citation:
PMID:  8502383     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evidence obtained from clinical studies, magnetoencephalography, and 31P magnetic resonance spectroscopy indicates that spreading depression is the underlying basis of migraine aura. Magnetoencephalographic and 31P magnetic resonance spectroscopic evidence also exists to explain interictal central neuronal hyperexcitability in migraine sufferers. A low intracellular brain magnesium concentration may be the link between the physiologic threshold for migraine and the attack itself.
Authors:
K M Welch; G L Barkley; N Tepley; N M Ramadan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurology     Volume:  43     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-06-28     Completed Date:  1993-06-28     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S21-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, MI 48202.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain / physiopathology*
Brain Chemistry
Cortical Spreading Depression / physiology
Female
Humans
Hydrogen-Ion Concentration
Magnesium / analysis
Magnetic Resonance Spectroscopy
Magnetoencephalography
Male
Middle Aged
Migraine Disorders / physiopathology*
Chemical
Reg. No./Substance:
7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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