| Central nervous system vasculopathy in neonatal lupus erythematosus. | |
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MedLine Citation:
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PMID: 8888046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central nervous system involvement in neonatal lupus erythematosus (NLE) has not been previously reported. We report four patients with NLE, all with complete congenital heart block and three with cerebral ultrasound and color Doppler flow imaging (CDFI) studies demonstrating evidence of associated vasculopathy in the gangliothalamic vasculature. CDFI confirmed blood flow through the affected vessels, indicating that blood flow was not compromised at this early stage. Short-term follow-up revealed no signs of progression of the vasculopathy, focal ischemia, gangliothalamic atrophy, or neurological impairment. Nevertheless, the implications of this finding with respect to the natural history of NLE remain to be defined, particularly in cases in which the disease develops into systemic lupus erythematosus later in life. Besides specific diagnostic studies for NLE, cerebral ultrasound, and CDFI studies are mandatory in all cases of complete congenital heart block, regardless of whether mothers are diagnosed as having connective-tissue disease or not. Neonates with signs of vasculopathy in the gangliothalamic region should be examined for NLE. |
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Authors:
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F Cabañas; A Pellicer; E Valverde; C Morales; J Quero |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 15 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-02-21 Completed Date: 1997-02-21 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 124-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, La Paz Hospital, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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blood Basal Ganglia / blood supply Blood Flow Velocity / physiology Brain Ischemia / congenital*, immunology, ultrasonography Cerebrovascular Disorders / congenital*, immunology, ultrasonography Female Humans Infant, Newborn Lupus Erythematosus, Systemic / congenital*, immunology, ultrasonography Male Regional Blood Flow / physiology Thalamus / blood supply Ultrasonography, Doppler, Color* Ultrasonography, Doppler, Transcranial* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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