Document Detail

Central nervous system toxicity associated with liposomal amphotericin B therapy for cutaneous leishmaniasis.
MedLine Citation:
PMID:  21460011     Owner:  NLM     Status:  MEDLINE    
AmBisome (liposomal amphotericin B) is used for prophylaxis and treatment of fungal infections, treatment of visceral leishmaniasis, and more recently, treatment of cutaneous leishmaniasis. Although the package insert cites neurologic toxicities in up to 20% of cases, review of the literature did not reveal any specific cases describing this side effect, particularly in a patient without comorbidities. We describe a healthy 38-year-old male treated with liposomal amphotericin B for cutaneous leishmaniasis acquired during military duties in Iraq. Shortly after completion of his treatment course, he reported memory difficulties and confusion. Further evaluation revealed no other source, and his cognitive issues were attributed to liposomal amphotericin B toxicity. These issues resolved over a few weeks, which is consistent with data about the drug's tissue penetration and metabolism available in the literature. This is a potential side effect of liposomal amphotericin B that can be observed in otherwise healthy patients.
Jessie S Glasser; Clinton K Murray
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  84     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-06-07     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  566-8     Citation Subset:  AIM; IM    
US Infectious Disease Service, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA.
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MeSH Terms
Amphotericin B / adverse effects*,  therapeutic use*
Antiprotozoal Agents / adverse effects,  therapeutic use
Confusion / chemically induced*
Leishmaniasis, Cutaneous / drug therapy*
Memory Disorders / chemically induced*
Reg. No./Substance:
0/Antiprotozoal Agents; 0/liposomal amphotericin B; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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