Document Detail

Central nervous system and the pathogenesis of hypertension. Sites and mechanisms.
MedLine Citation:
PMID:  1937689     Owner:  NLM     Status:  MEDLINE    
A large body of evidence indicates that the central nervous system plays an essential role in the pathogenesis of hypertension. However, in many cases the specific brain regions involved and the mechanisms by which these regions promote hypertension are not known. In recent years, research in this and other laboratories has attempted to determine the mechanisms by which neural and humoral signals arising in response to pathological conditions (often occurring in the periphery) interact with the central nervous system to produce hypertension. In this article, we illustrate the coupling of peripheral and central factors in the pathogenesis of hypertension by examining the central actions of angiotensin II and mineralocorticoids in the expression of renal hypertension and mineralocorticoid-salt hypertension, respectively. We also review recent data from this laboratory illustrating the involvement of medullary vasomotor centers in the development of neurogenic hypertension after sinoaortic deafferentation and in the maintenance of hypertension in the spontaneously hypertensive rat.
M J Brody; K J Varner; E C Vasquez; S J Lewis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Hypertension     Volume:  18     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-12-26     Completed Date:  1991-12-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  III7-12     Citation Subset:  IM    
Department of Pharmacology, University of Iowa College of Medicine, Iowa City.
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MeSH Terms
Brain / physiology*
Hypertension / etiology*
Hypertension, Renal / etiology
Medulla Oblongata / physiology
Grant Support
Reg. No./Substance:

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