| Central nervous system and the pathogenesis of hypertension. Sites and mechanisms. | |
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MedLine Citation:
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PMID: 1937689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A large body of evidence indicates that the central nervous system plays an essential role in the pathogenesis of hypertension. However, in many cases the specific brain regions involved and the mechanisms by which these regions promote hypertension are not known. In recent years, research in this and other laboratories has attempted to determine the mechanisms by which neural and humoral signals arising in response to pathological conditions (often occurring in the periphery) interact with the central nervous system to produce hypertension. In this article, we illustrate the coupling of peripheral and central factors in the pathogenesis of hypertension by examining the central actions of angiotensin II and mineralocorticoids in the expression of renal hypertension and mineralocorticoid-salt hypertension, respectively. We also review recent data from this laboratory illustrating the involvement of medullary vasomotor centers in the development of neurogenic hypertension after sinoaortic deafferentation and in the maintenance of hypertension in the spontaneously hypertensive rat. |
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Authors:
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M J Brody; K J Varner; E C Vasquez; S J Lewis |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Hypertension Volume: 18 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1991-12-26 Completed Date: 1991-12-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: III7-12 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Iowa College of Medicine, Iowa City. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / physiology* Desoxycorticosterone Humans Hypertension / etiology* Hypertension, Renal / etiology Medulla Oblongata / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-14388/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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64-85-7/Desoxycorticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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