Document Detail


Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis.
MedLine Citation:
PMID:  16335585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymphomas, both within and outside the central nervous system, are uncommon among patients with systemic lupus erythematosus (SLE). We describe a 58-year old Korean woman with SLE who presented with acute headache and confusion in the setting of prednisone and mycophenolate mofetil (MMF) therapy used to treat focal proliferative and membranous lupus nephritis. Three-dimensional brain magnetic resonance imaging (MRI) showed two peripherally ('ring') enhancing lesions within the basal ganglia, bilaterally, with associated mass effect and subfalcine herniation. A brain biopsy revealed an Epstein-Barr virus (EBV)-positive diffuse large B cell lymphoma. This is the first description of CNS lymphoma in a patient treated with MMF for lupus nephritis. While intracerebral lymphoma in the immunocompromised patient with lupus is rare, this disorder should be considered in the differential diagnosis of new-onset neurological symptoms among such patients.
Authors:
N Dasgupta; A C Gelber; F Racke; D M Fine
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Lupus     Volume:  14     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-02-09     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  910-3     Citation Subset:  IM    
Affiliation:
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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MeSH Terms
Descriptor/Qualifier:
Brain Neoplasms / etiology*,  pathology
Female
Humans
Immunosuppressive Agents / administration & dosage*
Lupus Nephritis / complications,  drug therapy*
Lymphoma, B-Cell / etiology*,  pathology
Middle Aged
Mycophenolic Acid / administration & dosage,  analogs & derivatives*
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 9242ECW6R0/mycophenolate mofetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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