Document Detail

Central nervous system lymphoma associated with mycophenolate mofetil in lupus nephritis.
MedLine Citation:
PMID:  16335585     Owner:  NLM     Status:  MEDLINE    
Lymphomas, both within and outside the central nervous system, are uncommon among patients with systemic lupus erythematosus (SLE). We describe a 58-year old Korean woman with SLE who presented with acute headache and confusion in the setting of prednisone and mycophenolate mofetil (MMF) therapy used to treat focal proliferative and membranous lupus nephritis. Three-dimensional brain magnetic resonance imaging (MRI) showed two peripherally ('ring') enhancing lesions within the basal ganglia, bilaterally, with associated mass effect and subfalcine herniation. A brain biopsy revealed an Epstein-Barr virus (EBV)-positive diffuse large B cell lymphoma. This is the first description of CNS lymphoma in a patient treated with MMF for lupus nephritis. While intracerebral lymphoma in the immunocompromised patient with lupus is rare, this disorder should be considered in the differential diagnosis of new-onset neurological symptoms among such patients.
N Dasgupta; A C Gelber; F Racke; D M Fine
Related Documents :
12352115 - Imaging of bilateral striopallidodentate calcinosis.
8151085 - Disseminated multifocal herpes zoster leukoencephalitis and subcortical hemorrhage in a...
12760425 - Magnetic resonance imaging findings in infantile spasms: etiologic and pathophysiologic...
9492095 - Adolescent case of alexander disease: mr imaging and mr spectroscopy.
16167745 - Inferior lumbar triangle hernia: case report.
7987785 - Agenesis of corpus callosum and dementia of the alzheimer's type: a review and case rep...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Lupus     Volume:  14     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-02-09     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  910-3     Citation Subset:  IM    
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Neoplasms / etiology*,  pathology
Immunosuppressive Agents / administration & dosage*
Lupus Nephritis / complications,  drug therapy*
Lymphoma, B-Cell / etiology*,  pathology
Middle Aged
Mycophenolic Acid / administration & dosage,  analogs & derivatives*
Reg. No./Substance:
0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 9242ECW6R0/mycophenolate mofetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Two cases of catastrophic antiphospholipid syndrome.
Next Document:  Endocarditis and ulnar artery aneurysm as presenting features of antiphospholipid syndrome and polya...