| Central nervous system lesions and segmental activity. | |
| | |
MedLine Citation:
|
PMID: 12171125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Study of activity in segmental pathways can help in understanding the pathophysiology of clinical disorders due to basal ganglia damage. Disynaptic Ia reciprocal inhibition (DI) acts by actively inhibiting antagonistic motoneurones and reducing the inhibition of agonist ones. During movement, activity of interneurones mediating DI is significantly modulated by descending inputs. In Parkinsonian patients, this descending modulation almost completely vanished. Lack of modulation was not dependent on L-DOPA as it occurred in treated patients and was not modified when patients were off medication. A potent heteronymous group II excitation of quadriceps MNs has been recently demonstrated in normal subjects after stimulation of the common peroneal nerve. This group II excitation was significantly enhanced in the rigid lower limb of Parkinsonian patients. We propose that enhanced group II excitation could contribute to rigidity in PD and result from a change in a tonic noradrenergic descending inhibitory control from locus coeruleus. |
| | |
Authors:
|
Sabine Meunier; Rose Katz; Marion Simonetta-Moreau |
Related Documents
:
|
17704435 - Application of bioelectrical impedance to clinical assessment of body composition in pe... 22897375 - Celiac disease and multiple sclerosis in the northwest of iran. 2029695 - Effects of levodopa and bromocriptine on blood pressure and plasma catecholamines in pa... 19224315 - Transcranial duplex in the differential diagnosis of parkinsonian syndromes: a systemat... 20880725 - Skin iron deposition characterises lipodermatosclerosis and leg ulcer. 15327725 - Neuropsychological results and neuropathological findings at autopsy in a case of mild ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Advances in experimental medicine and biology Volume: 508 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2002 |
Date Detail:
|
Created Date: 2002-08-12 Completed Date: 2003-03-12 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 309-13 Citation Subset: IM |
Affiliation:
|
Laboratoire de Neurophysiologie Clinique, Hĵpital de la Salpêtrière, Paris, France. meunier@chups.jussieu.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Efferent Pathways
/
physiopathology Humans Motor Neurons / physiology Neural Inhibition Parkinson Disease / physiopathology* Spinal Cord / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interspecies comparisons for the C3-C4 propriospinal system: unresolved issues.
Next Document: Reflex mechanisms for motor impairment in spinal cord injury.