| Central nervous system lesions associated with hereditary hemorrhagic telangiectasia--three case reports. | |
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MedLine Citation:
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PMID: 14560850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hereditary hemorrhagic telangiectasia (HHT) is easily overlooked in patients with central nervous system (CNS) lesions. Our clinical experience of three patients with CNS lesions associated with HHT stresses the importance of considering HHT. A 23-year-old male presented with consciousness disturbance and right hemiparesis. Emergency cerebral digital subtraction angiography revealed occlusion of the left middle cerebral artery and the left anterior cerebral artery. Pulmonary arteriography showed three pulmonary arteriovenous malformations (AVMs). A 62-year-old male presented with consciousness disturbance and sensory aphasia. Magnetic resonance imaging revealed a ring-enhanced lesion in the left temporal lobe which was removed by left frontotemporal craniotomy. The diagnosis was brain abscess. Chest computed tomography (CT) revealed two pulmonary AVMs. A 32-year-old female presented with progressive mild weakness in her left hand. Initial CT showed subcortical hemorrhage in the right frontal lobe. Cerebral angiography revealed no vascular malformations, but chest CT disclosed five pulmonary AVMs. All three patients had a family history of HHT. The possibility of HHT is important to consider in patients with cerebrovascular disease (CVD) or brain abscess to prevent complications, not only in the patients but also their blood relatives. Therefore, the medical and family history of patients with CVD or brain abscess should be investigated and HHT should be considered during the physical examination. |
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Authors:
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Kazuyuki Kuwayama; Kensaku Takase; Michiharu Kashihara; Hideki Hondo; Toshio Shigekiyo; Osamu Takimoto; Shunji Matsubara |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurologia medico-chirurgica Volume: 43 ISSN: 0470-8105 ISO Abbreviation: Neurol. Med. Chir. (Tokyo) Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-10-16 Completed Date: 2003-11-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0400775 Medline TA: Neurol Med Chir (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 447-51 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Tokushima Prefecturol Central Hospital, Tokushima. kny1717@yahoo.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Abscess / diagnosis, etiology*, therapy Cerebral Hemorrhage / diagnosis, etiology*, therapy Female Humans Intracranial Embolism / diagnosis, etiology*, therapy Male Middle Aged Telangiectasia, Hereditary Hemorrhagic / complications*, diagnosis, therapy |
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