Document Detail

Central nervous system involvement in optic neuritis.
MedLine Citation:
PMID:  6707669     Owner:  NLM     Status:  MEDLINE    
Thirty patients with clinically uncomplicated optic neuritis were subjected to a battery of electrophysiological tests, including visual evoked response (VER), auditory brainstem evoked response (ABER) and somatosensory evoked response (SSER). Blink reflex, electronystagmography (ENG), and computed tomography examinations were also carried out on all patients. These non-invasive tests indicated that in 11 of the 30 patients (37%), the optic neuritis was a symptom of subclinical multiple sclerosis, and that another five patients showed signs of mild central nervous system (CNS) involvement which may develop into multiple sclerosis later. This was confirmed by cerebrospinal fluid (CSF) analysis, using isoelectric focusing, showing oligoclonal extra bands in 11 out of these sixteen. A new classification of optic neuritis is proposed on the basis of these findings.
E A Sanders; J P Reulen; L A Hogenhuis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  47     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-05-16     Completed Date:  1984-05-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  241-9     Citation Subset:  IM    
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MeSH Terms
Brain / physiopathology*,  radiography
Evoked Potentials, Auditory
Evoked Potentials, Somatosensory
Evoked Potentials, Visual
Immunoglobulin G / cerebrospinal fluid
Multiple Sclerosis / complications*,  diagnosis
Optic Neuritis / etiology,  physiopathology*
Reg. No./Substance:
0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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