| Central nervous system congenital malformations in a developing country: issues and challenges against their prevention. | |
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MedLine Citation:
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PMID: 20091041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Little efforts are geared towards prevention of CNS anomalies in the developing countries. METHODS: A 1-year prospective cross-sectional analysis of the cases of CNS congenital anomalies seen in a Nigerian neurosurgical unit. This included both the children's and parents' sociodemographics, the profiles of the CNS anomalies, and the maternal obstetric health behaviors toward primary and/or secondary prevention of the anomalies. Statistical analysis was done with the Pearson's chi-square (or Fishers' exact) test. Level of significance set at P < 0.05. RESULTS: There were 54 cases of cranial and spinal gross CNS anomalies, including 32 neural tube defects; two thirds of the parents were low-income earners, and half had only basic education. Thirty percent of the pregnancies were unbooked; the mean gestational age (GA) at booking and commencement of obstetric micronutrient supplementation was 4.6 months. No case had periconceptional folic acid supplementation. Obstetric ultrasonography was performed late in pregnancy (mean GA 6 months), made positive diagnosis of CNS anomaly in only 14%, and was performed mainly in unsupervised private clinic settings in 98%. CONCLUSIONS: Little or no attention is currently paid to the prevention of CNS congenital anomalies in much of the low- and middle-income countries of the world. There is a great need to regulate the practice of obstetric ultrasonography in Nigeria. There is even a much greater, more fiercely urgent need to ensure periconceptional folic acid supplementation for all women of childbearing age through appropriate food fortification in these societies. |
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Authors:
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Amos Olufemi Adeleye; Magbagbeola D Dairo; Kayode G Olowookere |
Publication Detail:
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Type: Journal Article Date: 2010-01-21 |
Journal Detail:
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Title: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery Volume: 26 ISSN: 1433-0350 ISO Abbreviation: Childs Nerv Syst Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-09 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8503227 Medline TA: Childs Nerv Syst Country: Germany |
Other Details:
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Languages: eng Pagination: 919-24 Citation Subset: IM |
Affiliation:
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Division of Neurological Surgery, Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria. femdoy@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Sectional Studies Developing Countries Female Gestational Age Health Behavior Humans Infant Infant, Newborn Nervous System Malformations / epidemiology, prevention & control* Nigeria / epidemiology Obstetrics / statistics & numerical data Pregnancy Prenatal Care / statistics & numerical data Prospective Studies Socioeconomic Factors Ultrasonography, Prenatal / statistics & numerical data |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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