Document Detail

Central nervous system circuitry and peripheral neural sympathetic activity responsible for essential hypertension.
MedLine Citation:
PMID:  17109626     Owner:  NLM     Status:  MEDLINE    
Both clinical and experimental studies dealing with patients affected by idiopathic or essential hypertension (EH) are devoted to the great deal of physiological, pharmacological and pathological as well as therapeutical issues of EH. However, most articles devoted to EH do not refer to the central nervous system mechanisms underlying this disease and the channels which allow that these mechanisms are funneled to the peripheral autonomic nervous system and trigger this cardiovascular disorder. In the present review article we attempted to reach this target devoted to the central nervous system circuitry involved in the cardiovascular pathophysiology. We postulated that EH depends on the predominance of the binomial A5 noradrenergic (NA) nucleus + median raphe serotonergic (5-HT) nucleus over the (A6)-NA + dorsal raphe-5HT nuclei. This hypothesis receives additional support from our results obtained throughout the neuropharmacological therapy of this type of neurophysiological disorder. Our therapeutical strategy is addressed to enhance the activity of the (A6)-NA + dorsal raphe-5HT binomial circuitry.
Fuad Lechin; Bertha van der Dijs
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current neurovascular research     Volume:  3     ISSN:  1567-2026     ISO Abbreviation:  -     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-19     Completed Date:  2007-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208439     Medline TA:  Curr Neurovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  307-25     Citation Subset:  IM    
Department of Physiological Sciences, Section of Neurochemistry, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela.
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MeSH Terms
Acetylcholine / physiology
Autonomic Nervous System Diseases / physiopathology*
Autonomic Pathways / metabolism,  physiopathology*
Central Nervous System / anatomy & histology,  metabolism,  physiopathology*
Hypertension / physiopathology*
Norepinephrine / physiology
Raphe Nuclei / metabolism,  physiopathology
Serotonin / physiology
Sympathetic Fibers, Postganglionic / physiopathology*
Reg. No./Substance:
50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine

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