Document Detail


Central nervous system cardiovascular effects of bombesin in conscious rats.
MedLine Citation:
PMID:  3885756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of intracerebroventricular administration of bombesin on mean arterial pressure and heart rate were studied in conscious, freely moving rats. Injection of bombesin produced dose-dependent elevations of mean arterial pressure and reductions of heart rate. These effects were not caused by leakage of bombesin into the peripheral circulation. Adrenalectomy abolished the pressor action of bombesin but did not alter bombesin-induced bradycardia. Systemic phentolamine pretreatment prevented bombesin-induced changes of mean arterial pressure, whereas rats treated intravenously with captopril or a vasopressin antagonist still exhibited pressor responses to bombesin administration. Bombesin-induced bradycardia was partially antagonized by intravenous atropine methyl nitrate administration, whereas systemic injections of propranolol did not modify this response. It is concluded that bombesin acts within the central nervous system to elevate mean arterial pressure through an adrenal-dependent mechanism involving alpha-adrenergic receptors and to reduce heart rate through an adrenal-independent mechanism involving, at least in part, cardiac parasympathetic nervous activation.
Authors:
L A Fisher; C R Cave; M R Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  248     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-05-14     Completed Date:  1985-05-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H425-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine Vasopressin / analogs & derivatives,  pharmacology
Atropine Derivatives / pharmacology
Blood Pressure / drug effects
Bombesin / pharmacology*
Captopril / pharmacology
Cardiovascular System / drug effects*
Central Nervous System / drug effects*
Consciousness
Dose-Response Relationship, Drug
Heart Rate / drug effects
Injections, Intraventricular
Male
Peptides / pharmacology*
Phentolamine / pharmacology
Propranolol / pharmacology
Rats
Rats, Inbred Strains
Vasopressins / antagonists & inhibitors
Grant Support
ID/Acronym/Agency:
HL-32008/HL/NHLBI NIH HHS; NS-14263/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Atropine Derivatives; 0/Peptides; 11000-17-2/Vasopressins; 113-79-1/Arginine Vasopressin; 31362-50-2/Bombesin; 31610-87-4/methylatropine; 50-60-2/Phentolamine; 525-66-6/Propranolol; 62571-86-2/Captopril; 67269-08-3/argipressin, deaminopenicillamine(1)-O-methyl-Tyr(2)-

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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