Document Detail

Central nervous system actions of beta-endorphin on gastric acid secretion.
MedLine Citation:
PMID:  2954615     Owner:  NLM     Status:  MEDLINE    
We assessed the central nervous system (CNS) actions of beta-endorphin on gastric acid secretion in awake dogs. Synthetic beta-endorphin (0.2-2.0 nmol X kg-1), but not Leu- or Met-enkephalin, microinjected into the third cerebral ventricle, significantly (P less than 0.01) decreased gastric acid secretion stimulated by pentagastrin. beta-Endorphin given intracerebroventricularly inhibited gastric acid secretion following 2-deoxy-D-glucose (P less than 0.01), but not after stimulation with histamine. Intravenous administration of beta-endorphin did not inhibit gastric acid secretion. beta-Endorphin decreased gastric acid secretion but not the concomitant release of gastrin stimulated by a 200-ml liquid meal containing 8% peptone. Pretreatment of the animals with the opioid antagonist, naloxone, prevented the gastric inhibitory effect of beta-endorphin. Furthermore, either ganglionic blockade with chlorisondamine or truncal vagotomy completely abolished the gastric inhibitory action of beta-endorphin. These findings indicate that beta-endorphin, but neither Leu- nor Met-enkephalin, acts within the CNS to inhibit gastric acid secretion in awake dogs. beta-Endorphin-induced inhibition of gastric acid secretion is mediated by an opiate-dependent pathway and by the autonomic (parasympathetic) nervous system.
H J Lenz; M R Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  413     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-08-12     Completed Date:  1987-08-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
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MeSH Terms
Autonomic Nervous System / drug effects
Brain / drug effects*
Endorphins / pharmacology*
Enkephalin, Leucine / pharmacology
Enkephalin, Methionine / pharmacology
Gastric Acid / secretion*
Injections, Intraventricular
Naloxone / pharmacology
Pentagastrin / antagonists & inhibitors
Vagus Nerve / drug effects
Grant Support
Reg. No./Substance:
0/Endorphins; 465-65-6/Naloxone; 5534-95-2/Pentagastrin; 58569-55-4/Enkephalin, Methionine; 58822-25-6/Enkephalin, Leucine; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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