| Central nervous system action of bombesin to inhibit gastric acid secretion. | |
| | |
MedLine Citation:
|
PMID: 2409424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bombesin or gastrin releasing peptide injected into the lateral, third, or fourth ventricle, or into the cisterna magna, inhibited gastric acid secretion induced by a wide variety of gastric acid stimulants in several animal models. Studies of bombesin microinfusion into specific hypothalamic nuclei of intact rats, or injection into the cisterna magna of midbrain transected rats, indicated that the peptide can trigger inhibition of gastric acid secretion from both forebrain and hindbrain structures. The neural pathways mediating bombesin action required the integrity of the cervical spinal cord; the vagus did not play an important role. Spantide, a substance P and bombesin receptor antagonist, was not useful in studying the physiological role of bombesin. This was due both to its inability to reverse the central action of bombesin on gastric secretion, and to its in vivo toxicity. |
| | |
Authors:
|
Y Tache; M Gunion |
Related Documents
:
|
3108064 - Gastric acidification inhibits meal-stimulated gastric acid secretion after prostagland... 16710054 - Distinct mechanisms of acid-induced hco3- secretion in normal and slightly permeable st... 7719644 - A comparative catabolism study of isoleucine by insect and mammalian tissues. 11787764 - Pharmacological regulation of gastric acid secretion in the apical membrane of parietal... 7328564 - Demonstration of chemotactic factor in human gout: further characterization of occurren... 14660344 - Carbon source-induced modifications in the mycolic acid content and cell wall permeabil... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Life sciences Volume: 37 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1985 Jul |
Date Detail:
|
Created Date: 1985-08-20 Completed Date: 1985-08-20 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 115-23 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bombesin / administration & dosage, pharmacology* Brain Stem / drug effects, physiology Cats Dogs Gastric Acid / secretion* Gastrin-Releasing Peptide Humans Hypothalamus / drug effects*, physiology Injections, Intraventricular Neurosecretion / drug effects Parietal Cells, Gastric / secretion* Peptides / administration & dosage, pharmacology* Rats Secretory Rate / drug effects Species Specificity Substance P / analogs & derivatives, pharmacology Swine |
| Grant Support | |
ID/Acronym/Agency:
|
AM17328-11/AM/NIADDK NIH HHS; AM30110-03/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Peptides; 31362-50-2/Bombesin; 33507-63-0/Substance P; 80043-53-4/Gastrin-Releasing Peptide; 91224-37-2/spantide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High affinity receptors for bombesin/GRP-like peptides on human small cell lung cancer.
Next Document: Centrally-mediated bombesin effects on gastrointestinal motility.