| Central nervous system abscesses due to Coccidioides species. | |
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MedLine Citation:
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PMID: 8838179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Meningitis occurs in one-third to one-half of patients with disseminated coccidioidomycosis, but mass lesions have rarely been described; these lesions are usually found at autopsy. We report six cases of disseminated coccidioidomycosis with central nervous system (CNS) abscesses. Four patients had cerebellar involvement, and two had spinal cord involvement. Four patients were diabetic, and two subsequently died. Review of the literature on CNS coccidioidomycosis indicated that parenchymal brain involvement occurs in 1%-33% of cases, and < 40 cases with mass lesions have been reported since 1905. Almost all patients were male and had other active disseminated foci of coccidioidomycosis. In approximately one-third of all cases, meningitis was absent. Brain lesions may be superficial or deep and multiple or single. In the absence of meningitis, serology of cerebrospinal fluid is negative. Hematogenous origin appears to be more common than direct extension from the meninges. Spinal cord involvement is rare. Diabetes was present in several cases, thus suggesting a vascular predisposition. We hope our experience will increase awareness of this entity, which appears to be more common than previously appreciated, and will facilitate diagnosis. |
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Authors:
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A F Bañuelos; P L Williams; R H Johnson; S Bibi; D N Fredricks; S A Gilroy; S U Bhatti; J Aguet; D A Stevens |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 22 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-12-03 Completed Date: 1996-12-03 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 240-50 Citation Subset: IM |
Affiliation:
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Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128-2699, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abscess*
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microbiology,
pathology Adolescent Adult Brain Abscess* / microbiology, pathology Cerebellar Diseases* / microbiology, pathology Cerebellum / microbiology, pathology Child, Preschool Coccidioides / isolation & purification Coccidioidomycosis* / microbiology, pathology Female Humans Male Middle Aged Spinal Cord / microbiology, pathology Spinal Cord Diseases* / microbiology, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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