Document Detail

Central natriuretic peptides regulation of peripheral atrial natriuretic factor release.
MedLine Citation:
PMID:  10828498     Owner:  NLM     Status:  MEDLINE    
Atrial natriuretic factor (ANF) and C-type natriuretic peptide (CNP) receptors have been described in encephalic areas and nuclei related to the regulation of cardiovascular as well as sodium and water homeostasis. Stimulation of the anterior ventral third ventricular region of the brain modifies plasma ANF concentration, suggesting the participation of the central nervous system in the regulation of circulating ANF. The aim of this work was to study the effect of centrally applied ANF or CNP on plasma ANF. Normal and blood volume expanded rats (0.8 ml isotonic saline/100 g body weight) were intra cerebralventricularly injected with 1, 10 or 100 ng/microl/min ANF. Blood volume expanded animals were also centrally injected with the same doses of CNP. Blood samples were collected at 5 and 15 min. after intracerebralventricular administration of either ANF or CNP. Centrally applied ANF did not affect circulating ANF in normal blood volume rats. In blood volume expanded animals both ANF (1, 10 or 100 ng/microl/min) and CNP (1 ng/microl/min) decreased plasma ANF concentration after 15 min. Moreover, CNP (10 and 100 ng/microl/min) lowered circulating ANF levels not only at 15 min but also at 5 min. Neither ANF nor CNP elicited any change in mean arterial pressure and heart rate in normal and blood volume expanded rats. These results suggest the existence of a central regulation exerted by natriuretic peptides on circulating ANF levels. Furthermore, this is the first study reporting an effect on plasma ANF induced by centrally applied CNP.
A M Puyó; M S Vatta; A S Donoso; L G Bianciotti; B E Fernández
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory peptides     Volume:  90     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-16     Completed Date:  2000-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  93-9     Citation Subset:  IM    
Cátedra de Biología Celular e Histología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires-Consejo de Investigaciones Científicas y Técnicas (CONICET), Junín 956, Capital Federal, 5 degrees piso, (1113), Buenos Aires, Argentina.
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MeSH Terms
Arteries / drug effects
Atrial Natriuretic Factor / administration & dosage,  blood,  metabolism*
Blood Pressure / drug effects
Brain / metabolism*
Heart Atria / drug effects,  metabolism*
Heart Rate / drug effects
Natriuretic Peptide, C-Type / administration & dosage,  metabolism*
Rats, Wistar
Reg. No./Substance:
127869-51-6/Natriuretic Peptide, C-Type; 85637-73-6/Atrial Natriuretic Factor

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