Document Detail

Central melanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat.
MedLine Citation:
PMID:  21172367     Owner:  NLM     Status:  MEDLINE    
The hypothalamic melanocortin system is known for its role in regulating energy homeostasis through it actions within hypothalamic brain centers. However, emerging evidence suggests that this system regulates addictive behaviors through signaling within mesolimbic neurons. Here, we hypothesized the melanocortin system modulates feeding behavior through its actions on mesolimbic neurons. In particular, we predicted that central administration of the melanocortin antagonist agouti-related peptide (AgRP) would activate midbrain dopamine neurons, increase mesolimbic dopamine turnover, and alter food seeking behaviors. We found that intraventricular administration of agouti-related peptide increased neuronal activation within midbrain dopamine neurons in addition to increasing dopamine turnover in the medial prefrontal cortex. Additionally, using the conditioned place preference paradigm to assay food seeking behavior, we report that central injection of agouti-related peptide attenuates the acquisition of a conditioned place preference for sucrose, but not high fat diet. These results suggest that the melanocortin system is capable of regulating mesocorticolimbic activity and food seeking behavior.
Jon F Davis; Derrick L Choi; Jennifer D Shurdak; Eric G Krause; Maureen F Fitzgerald; Jack W Lipton; Randall R Sakai; Stephen C Benoit
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Publication Detail:
Type:  Journal Article     Date:  2010-12-21
Journal Detail:
Title:  Physiology & behavior     Volume:  102     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-15     Completed Date:  2011-06-21     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  491-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA.
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MeSH Terms
Agouti-Related Protein / administration & dosage,  pharmacology*
Conditioning (Psychology) / drug effects
Dietary Fats / pharmacology
Dopamine / metabolism
Feeding Behavior / drug effects,  physiology*
Injections, Intraventricular
Melanocortins / drug effects,  physiology*
Neurons / metabolism,  physiology*
Nucleus Accumbens / drug effects,  metabolism*
Peptide Fragments / administration & dosage,  pharmacology*
Prefrontal Cortex / drug effects,  metabolism*
Rats, Long-Evans
Sucrose / pharmacology
Ventral Tegmental Area / drug effects,  metabolism*
Grant Support
R01 DK066223-04/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Agouti-Related Protein; 0/Dietary Fats; 0/Melanocortins; 0/Peptide Fragments; 0/agouti-related peptide, (Yc(CRFFNAFC)Y); 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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