| Central mechanisms of osmosensation and systemic osmoregulation. | |
| | |
MedLine Citation:
|
PMID: 18509340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Systemic osmoregulation is a vital process whereby changes in plasma osmolality, detected by osmoreceptors, modulate ingestive behaviour, sympathetic outflow and renal function to stabilize the tonicity and volume of the extracellular fluid. Furthermore, changes in the central processing of osmosensory signals are likely to affect the hydro-mineral balance and other related aspects of homeostasis, including thermoregulation and cardiovascular balance. Surprisingly little is known about how the brain orchestrates these responses. Here, recent advances in our understanding of the molecular, cellular and network mechanisms that mediate the central control of osmotic homeostasis in mammals are reviewed. |
| | |
Authors:
|
Charles W Bourque |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-05-29 |
Journal Detail:
|
Title: Nature reviews. Neuroscience Volume: 9 ISSN: 1471-0048 ISO Abbreviation: Nat. Rev. Neurosci. Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-06-23 Completed Date: 2008-07-25 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 100962781 Medline TA: Nat Rev Neurosci Country: England |
Other Details:
|
Languages: eng Pagination: 519-31 Citation Subset: IM |
Affiliation:
|
Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Room L7-216, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada. charles.bourque@mcgill.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / anatomy & histology, metabolism Extracellular Fluid / chemistry, metabolism Homeostasis* Humans Ion Channels / metabolism Osmolar Concentration* Osmotic Pressure* Sensory Receptor Cells / metabolism* Signal Transduction / physiology Sodium / metabolism Thirst / physiology Water-Electrolyte Balance / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Ion Channels; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.
Next Document: KIR2DL5 alleles mark certain combination of activating KIR genes.