Document Detail

Central mechanisms of osmosensation and systemic osmoregulation.
MedLine Citation:
PMID:  18509340     Owner:  NLM     Status:  MEDLINE    
Systemic osmoregulation is a vital process whereby changes in plasma osmolality, detected by osmoreceptors, modulate ingestive behaviour, sympathetic outflow and renal function to stabilize the tonicity and volume of the extracellular fluid. Furthermore, changes in the central processing of osmosensory signals are likely to affect the hydro-mineral balance and other related aspects of homeostasis, including thermoregulation and cardiovascular balance. Surprisingly little is known about how the brain orchestrates these responses. Here, recent advances in our understanding of the molecular, cellular and network mechanisms that mediate the central control of osmotic homeostasis in mammals are reviewed.
Charles W Bourque
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-05-29
Journal Detail:
Title:  Nature reviews. Neuroscience     Volume:  9     ISSN:  1471-0048     ISO Abbreviation:  Nat. Rev. Neurosci.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-07-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100962781     Medline TA:  Nat Rev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  519-31     Citation Subset:  IM    
Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Room L7-216, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada.
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MeSH Terms
Brain / anatomy & histology,  metabolism
Extracellular Fluid / chemistry,  metabolism
Ion Channels / metabolism
Osmolar Concentration*
Osmotic Pressure*
Sensory Receptor Cells / metabolism*
Signal Transduction / physiology
Sodium / metabolism
Thirst / physiology
Water-Electrolyte Balance / physiology*
Reg. No./Substance:
0/Ion Channels; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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