Document Detail

Central mechanisms during fatiguing muscle exercise in muscular dystrophy and fibromyalgia syndrome: A study with transcranial magnetic stimulation.
MedLine Citation:
PMID:  21305574     Owner:  NLM     Status:  Publisher    
Introduction: The aim of this study was to apply paired-pulse transcranial magnetic stimulation (TMS) to assess intracortical inhibition (ICI) during fatiguing muscle exercise in healthy humans and patients with muscular dystrophy (MD) and fibromyalgia syndrome (FMS) to obtain insight into differential central mechanisms. Methods: We studied 23 patients with MD, 16 patients with FMS, and 23 healthy controls. All participants performed a fatiguing motor task. TMS recordings were taken pre-exercise, immediately post-exercise, and 40 minutes post-exercise. Results: ICI was already reduced pre-exercise in MD and FMS, whereas ICI decreased significantly during fatiguing muscle exercise only in healthy subjects. Discussion: Reduced baseline ICI in patients might prevent further utilization of this presumably compensatory mechanism during fatiguing muscle exercise. Although reduced baseline to be ICI in MD can be explained as compensatory due to peripheral weakness, in FMS reduced ICI must be considered an indicator of primary central disinhibition. Muscle Nerve, 2011.
Peter Schwenkreis; Michael Voigt; Monika Hasenbring; Martin Tegenthoff; Matthias Vorgerd; Rudolf A Kley
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-8
Journal Detail:
Title:  Muscle & nerve     Volume:  -     ISSN:  1097-4598     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
Department of Neurology, BG-Universitätsklinikum Bergmannsheil, Ruhr University, Buerkle-de-la-Camp-Platz 1, Bochum D-44789, Germany.
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