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Central lower attenuating lesion in the ablation zone on immediate follow-up CT after percutaneous radiofrequency ablation for hepatocellular carcinoma: incidence and clinical significance.
MedLine Citation:
PMID:  19467813     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
PURPOSE: The purpose of this study was to evaluate the incidence of central lower attenuating (CLA) lesion in the ablation zone seen on immediate follow-up CT images after percutaneous radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC), and the correlation of CLA lesions and local tumor progression (LTP).
SUBJECTS AND METHODS: The study group included 146 patients with 167 ablation zones that had undergone follow-up CT examinations for more than 12 months after percutaneous RFA. CLA lesions corresponding to index tumors and ablative margins (safety margins) were evaluated in the ablation zones seen on immediate follow-up CT including coronal and sagittal multiplanar reformatted (MPR) images with narrow window width settings.
RESULTS: CLA lesions were depicted on 48 of 167 ablation zones (28.7%) on immediate follow-up CT images. Among the 48 ablation zones with CLA lesions, 27 (56.3%, 27/48) had ablative margins on all three of the orthogonal MPR images and they showed no LTP (0%) on follow-up CT examinations. Three of the ablation zones with CLA lesions (6.3%, 3/48) having an ablative margin on one plane only also showed no LTP (0%). LTP was observed in 2 of 18 ablation zones (11.1%) that had CLA lesions without ablative margins on all three planes. In the remaining 119 ablation zones without CLA lesions, 5 (4.2%, 5/119) showed LTP.
CONCLUSION: CLA lesions in ablation zones were occasionally (28.7%) seen on immediate follow-up CT images after RFA for HCCs. The presence of CLA lesions with ablative margins might be a negative predictor of LTP.
Authors:
Yulri Park; Dongil Choi; Hyunchul Rhim; Young-sun Kim; Ji Young Lee; Ilsoo Chang; Hyo K Lim; Cheol Keun Park
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Publication Detail:
Type:  Journal Article     Date:  2009-05-20
Journal Detail:
Title:  European journal of radiology     Volume:  75     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, #50, Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea.
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