Document Detail


Central litorin injection is associated with primary anorexigenic effects that coincide with activation of the magnocellular division of the paraventricular nucleus.
MedLine Citation:
PMID:  20116849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The central mechanism that mediates litorin-induced satiety is poorly understood, and has not been studied in a non-mammalian species. Therefore, the aim of this study was to determine if litorin-induced satiety in an alternative vertebrate model, the chick, and to elucidate some of the central mechanisms that are associated with this response. In Experiment 1, chicks responded to intracerebroventricular (ICV) injection of litorin with reduced food intake at all doses tested (0.1, 1.0, and 10 nmol), while concurrently, an anti-dipsogenic effect was observed in the two higher doses tested. Whole blood glucose concentrations were not affected. In Experiment 2, chicks that were food-withheld did not reduce their water intake after ICV litorin injection. To determine if litorin affected behaviors unrelated to ingestion, a comprehensive behavior analysis was conducted as Experiment 3. Of the behaviors observed, only the number of feeding pecks was reduced. Other behaviors such as movement, defecation, escape, posture, or deep rest were not affected. Lastly, in Experiment 4, litorin-treated chicks had an increased number of c-Fos immunoreactive cells in the magnocellular division of the paraventricular nucleus. The arcuate nucleus, dorsomedial nucleus, lateral hypothalamus, parvicellular division of the paraventricular nucleus, suprachiasmatic nucleus, periventricular nucleus and the ventromedial hypothalamus were not affected. Therefore, we conclude that ICV litorin causes anorexigenic effects in chicks associated with changes in hypothalamic chemistry that appear to be behavior specific.
Authors:
Mark A Cline; Stuart A Cofield; Tetsuya Tachibana
Related Documents :
23406919 - Comparative evaluation of the influence of television advertisements on children and ca...
24202289 - Aluminium and calcium in soil and food from guam, palau and jamaica: implications for a...
8616609 - The interaction of clonidine and nitric oxide on feeding behavior in the chicken.
9751529 - A c-terminal fragment of agouti-related protein increases feeding and antagonizes the e...
8322979 - Caudal hindbrain participation in the suppression of feeding by central and peripheral ...
24915349 - Umami taste components and their sources in asian foods.
19577379 - Potential complementarity of high-flavanol cocoa powder and spirulina for health protec...
10221879 - Gnathostomosis, an emerging foodborne zoonotic disease in acapulco, mexico.
20211329 - Dietary fish intake and incident atrial fibrillation (from the women's health initiative).
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-08
Journal Detail:
Title:  Neuropeptides     Volume:  44     ISSN:  1532-2785     ISO Abbreviation:  Neuropeptides     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biology (6931), Radford University, Radford, VA 24142, USA. mcline@radford.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / administration & dosage*
Blood Glucose / drug effects
Cell Division
Chickens
Drinking / drug effects
Feeding Behavior / drug effects*
Genes, fos / drug effects
Injections, Intraventricular
Oligopeptides / administration & dosage*
Paraventricular Hypothalamic Nucleus / cytology,  drug effects*
Satiety Response / drug effects*
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Blood Glucose; 0/Oligopeptides; 55749-97-8/litorin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Wake promoting effects of cocaine and amphetamine-regulated transcript (CART).
Next Document:  Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents.