Document Detail

Central litorin injection is associated with primary anorexigenic effects that coincide with activation of the magnocellular division of the paraventricular nucleus.
MedLine Citation:
PMID:  20116849     Owner:  NLM     Status:  MEDLINE    
The central mechanism that mediates litorin-induced satiety is poorly understood, and has not been studied in a non-mammalian species. Therefore, the aim of this study was to determine if litorin-induced satiety in an alternative vertebrate model, the chick, and to elucidate some of the central mechanisms that are associated with this response. In Experiment 1, chicks responded to intracerebroventricular (ICV) injection of litorin with reduced food intake at all doses tested (0.1, 1.0, and 10 nmol), while concurrently, an anti-dipsogenic effect was observed in the two higher doses tested. Whole blood glucose concentrations were not affected. In Experiment 2, chicks that were food-withheld did not reduce their water intake after ICV litorin injection. To determine if litorin affected behaviors unrelated to ingestion, a comprehensive behavior analysis was conducted as Experiment 3. Of the behaviors observed, only the number of feeding pecks was reduced. Other behaviors such as movement, defecation, escape, posture, or deep rest were not affected. Lastly, in Experiment 4, litorin-treated chicks had an increased number of c-Fos immunoreactive cells in the magnocellular division of the paraventricular nucleus. The arcuate nucleus, dorsomedial nucleus, lateral hypothalamus, parvicellular division of the paraventricular nucleus, suprachiasmatic nucleus, periventricular nucleus and the ventromedial hypothalamus were not affected. Therefore, we conclude that ICV litorin causes anorexigenic effects in chicks associated with changes in hypothalamic chemistry that appear to be behavior specific.
Mark A Cline; Stuart A Cofield; Tetsuya Tachibana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-08
Journal Detail:
Title:  Neuropeptides     Volume:  44     ISSN:  1532-2785     ISO Abbreviation:  Neuropeptides     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Department of Biology (6931), Radford University, Radford, VA 24142, USA.
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MeSH Terms
Appetite Depressants / administration & dosage*
Blood Glucose / drug effects
Cell Division
Drinking / drug effects
Feeding Behavior / drug effects*
Genes, fos / drug effects
Injections, Intraventricular
Oligopeptides / administration & dosage*
Paraventricular Hypothalamic Nucleus / cytology,  drug effects*
Satiety Response / drug effects*
Reg. No./Substance:
0/Appetite Depressants; 0/Blood Glucose; 0/Oligopeptides; 55749-97-8/litorin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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