Document Detail

Central leptin and ghrelin signalling: Comparing and contrasting their mechanisms of action in the brain.
MedLine Citation:
PMID:  21331644     Owner:  NLM     Status:  Publisher    
In the past two decades, two major discoveries have greatly contributed to our current knowledge on the central control of food intake and body-weight; the discovery of the anorexigenic adipocyte derived hormone leptin in 1994 and the orexigenic gut derived hormone ghrelin in 1999. Both hormones act as crucial signals to indicate nutritional status as well as to modulate feeding behaviour through a variety of distinct pathways. They target overlapping CNS regions in order to mediate their obvious opposing effects on energy balance. Here we depict the integral picture of leptin and ghrelin on central regulation of food intake by reviewing their actions across the CNS, in regions of the hypothalamus, brainstem, mesolimbic reward pathway and other higher brain areas.
Xiaoye Shan; Giles S H Yeo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-18
Journal Detail:
Title:  Reviews in endocrine & metabolic disorders     Volume:  -     ISSN:  1573-2606     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100940588     Medline TA:  Rev Endocr Metab Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Cambridge Metabolic Research Labs, Level 4, Institute of Metabolic Science, Addenbrooke's Hospital, Box 289, Cambridge, CB2 0QQ, UK.
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