| Central indomethacin enhances volume-dependent vasopressin release. | |
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MedLine Citation:
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PMID: 6391207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of centrally administered indomethacin on hemorrhage-induced vasopressin release was studied in the morphine-sedated, urethan/chloralose-anesthetized dog. Ventriculocisternal perfusion of indomethacin 1) significantly reduced the amount of prostaglandin E2 in the effluent from the cisterna magna, 2) significantly enhanced the vasopressin response to volume depletion, and led to a greater fall in mean arterial blood pressure during severe hemorrhage. The results suggest that central prostaglandins may have an inhibitory effect on vasopressin secretion during volume depletion. |
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Authors:
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D P Brooks; L Share; J T Crofton; A Nasjletti |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 247 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-01-24 Completed Date: 1985-01-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R1017-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cerebral Hemorrhage / blood, metabolism, physiopathology Cisterna Magna / metabolism Dogs Heart Rate / drug effects Indomethacin / administration & dosage*, pharmacology Injections, Intraventricular Male Osmolar Concentration Prostaglandins E / metabolism Renin / blood Vasopressins / blood, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HL-12990/HL/NHLBI NIH HHS; HL-19209/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 11000-17-2/Vasopressins; 53-86-1/Indomethacin; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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