Document Detail

Central hyperventilation related to administration of topiramate.
MedLine Citation:
PMID:  10788749     Owner:  NLM     Status:  MEDLINE    
Topiramate is a recently released antiepileptic agent used in the treatment of patients with refractory seizure disorders. In addition to its antiepileptogenic activities, it results in inhibition of carbonic anhydrase isoenzymes II and IV, which are present in the central nervous system. A 15-year-old female who presented with hyperpnea and primary respiratory alkalosis is reported. Other possible etiologies of the central hyperventilation syndrome were excluded. The problem resolved within 24 hours after discontinuing topiramate.
A L Laskey; D E Korn; B I Moorjani; N C Patel; J D Tobias
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  22     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-31     Completed Date:  2000-05-31     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-8     Citation Subset:  IM    
Department of Child Health, University of Missouri, Columbia, MO 65212, USA.
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MeSH Terms
Anticonvulsants / adverse effects*
Bicarbonates / blood
Chlorides / blood
Epilepsy / blood,  drug therapy*
Fructose / adverse effects,  analogs & derivatives*
Hyperventilation / chemically induced*
Sodium / blood
Reg. No./Substance:
0/Anticonvulsants; 0/Bicarbonates; 0/Chlorides; 0H73WJJ391/topiramate; 30237-26-4/Fructose; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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