Document Detail

Central haemodynamics and regional blood flow during halothane-nitrous oxide anaesthesia and controlled ventilation. An experimental study in the rat.
MedLine Citation:
PMID:  6612099     Owner:  NLM     Status:  MEDLINE    
The haemodynamic effects of halothane-N2O/O2 anaesthesia with controlled ventilation were studied in rats, using the microsphere method. Mean arterial blood pressure was significantly reduced but only minor effects on cardiac output (CO), heart rate, and systemic vascular resistance were seen. During anaesthesia, there were significantly increased fractions of CO delivered to brain, lungs, small intestine and liver (hepatic artery), while the fractions to spleen, stomach and carcass were decreased. Fractional distribution and regional blood flow to heart, kidneys, adrenals and preportal area remained unchanged. When anaesthesia was prolonged from 60 to 90 min, no further changes in central or regional haemodynamics were seen. Considering the minor effects on central haemodynamics and the absence of changes in central and regional haemodynamics at 60 and 90 min, this anaesthesia model should be useful in experimental research.
C Gustafson; K F Aronsen; J Idvall; B Rosberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie     Volume:  182     ISSN:  0300-9130     ISO Abbreviation:  Res Exp Med (Berl)     Publication Date:  1983  
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0324736     Medline TA:  Res Exp Med (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  193-201     Citation Subset:  IM    
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MeSH Terms
Anesthesia, General*
Blood Pressure
Cardiac Output
Heart Rate
Nitrous Oxide*
Rats, Inbred Strains
Regional Blood Flow
Respiration, Artificial*
Time Factors
Vascular Resistance
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 151-67-7/Halothane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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