Document Detail

Central haemodynamics in experimental acute pancreatitis.
MedLine Citation:
PMID:  10433147     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate central haemodynamics in severe and mild acute pancreatitis in pigs. DESIGN: Randomised controlled experiment. SETTING: Animal laboratory, Finland. SUBJECTS: 24 domestic pigs weighing 21-27 kg. INTERVENTIONS: In 8 anaesthetised and mechanically ventilated pigs the pancreatic duct was cannulated and taurocholic acid was infused to induce severe acute pancreatitis. Eight animals received intraductal saline infusion and developed mild acute pancreatitis. Eight pigs were cannulated alone and served as controls. MAIN OUTCOME MEASURES: Cardiac index, heart rate, mean arterial pressure, central venous pressure, mean pulmonary arterial pressure, pulmonary arterial occlusion pressure, haemoglobin, arterial blood gases and acid base balance. RESULTS: Intraductally infused taurocholic acid rapidly induced severe necrotising acute pancreatitis as assessed both macroscopically and histologically. Histological changes of mild acute pancreatitis were seen in animals after intraductal saline infusion. Central haemodynamics, arterial blood gases, and acid base balances were stable throughout the study period in all groups. The main finding was haemoconcentration as indicated by the increase in arterial haemoglobin concentration in pigs with mild and severe acute pancreatitis. CONCLUSION: Haemoconcentration precedes central haemodynamic alterations in experimental acute pancreatitis.
P J Kinnala; K T Kuttila; J M Grönroos; T V Havia; T J Nevalainen; J Niinikoski
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of surgery = Acta chirurgica     Volume:  165     ISSN:  1102-4151     ISO Abbreviation:  Eur J Surg     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-09-03     Completed Date:  1999-09-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9105264     Medline TA:  Eur J Surg     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  598-603     Citation Subset:  IM    
Department of Surgery, University of Turku, Finland.
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MeSH Terms
Acute Disease
Cholagogues and Choleretics
Hemodynamics / physiology*
Hemoglobins / analysis
Pancreatitis, Acute Necrotizing / chemically induced,  physiopathology*
Taurocholic Acid
Time Factors
Reg. No./Substance:
0/Cholagogues and Choleretics; 0/Hemoglobins; 81-24-3/Taurocholic Acid

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