Document Detail

Central haemodynamic effects of dextran 70, dihydroergotamine and their combination. A study in dogs.
MedLine Citation:
PMID:  6195855     Owner:  NLM     Status:  MEDLINE    
In a study in dogs the central haemodynamic effects of dextran 70 and dihydroergotamine, both separated and combined, were evaluated. Dextran 70 gave an increased cardiac output, and peripheral resistance was reduced. The volume of blood flow in the femoral vein increased, pressure recordings being mainly unchanged. Dihydroergotamine caused an increase in the systemic arterial, central venous and pulmonary artery pressure. Cardiac output was unchanged. Total peripheral resistance increased but pulmonary vascular resistance remained unchanged. The combination of dextran 70 and dihydroergotamine gave a rather more pronounced increase in pressure recordings, but the other parameters observed were only moderately affected.
B Lindblad; D Bergqvist
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta chirurgica Scandinavica     Volume:  149     ISSN:  0001-5482     ISO Abbreviation:  Acta Chir Scand     Publication Date:  1983  
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906530     Medline TA:  Acta Chir Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  459-65     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Blood Volume / drug effects
Cardiac Output / drug effects
Dextrans / pharmacology*
Dihydroergotamine / pharmacology*
Hemodynamics / drug effects*
Stroke Volume / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
511-12-6/Dihydroergotamine; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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