| Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases. | |
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MedLine Citation:
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PMID: 16504869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical behavior of central giant cell granuloma (CGCG) of the jaws is variable and difficult to predict. Clinical data and follow-up information of 26 patients with CGCG were analyzed. Histologic features were correlated with the clinical course of the disease. In 16 patients the CGCGs were asymptomatic; 10 lesions presented with aggressive growth, pain, massive swelling, root resorption, cortical perforation, and/or recurrence. These patients were younger and the lesions were larger than in the nonaggressive group. The histomorphometric analysis proved a significant increase in large giant cells, fractional surface area, and mitotic activity in aggressive CGCG lesions. Immunohistologic investigation (Ki-67 and p53 stain) revealed no significant differences. After surgical treatment, 3 patients with aggressive lesions developed a recurrence. The data show that clinical and histomorphometric features may be reliable indicators for the differentiation between aggressive and nonaggressive CGCG. This should be accounted for to improve the individual planning of the treatment and follow-up. |
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Authors:
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Birgit Kruse-Lösler; Raihanatou Diallo; Christoph Gaertner; Karl-Ludwig Mischke; Ulrich Joos; Johannes Kleinheinz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 101 ISSN: 1528-395X ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-28 Completed Date: 2006-03-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: 346-54 Citation Subset: D; IM |
Affiliation:
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Department of Craniomaxillofacial Surgery, University of Münster, Münster, Germany. losler@uni-muenster.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Child Child, Preschool Discriminant Analysis Female Follow-Up Studies Granuloma, Giant Cell / genetics, pathology*, radiography, surgery Humans Immunohistochemistry Jaw Diseases / genetics, pathology*, radiography, surgery Ki-67 Antigen / analysis Male Middle Aged Nucleic Acid Hybridization Prognosis Retrospective Studies Sex Ratio Tumor Suppressor Protein p53 / analysis |
| Chemical | |
Reg. No./Substance:
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0/Ki-67 Antigen; 0/Tumor Suppressor Protein p53 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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