Document Detail

Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases.
MedLine Citation:
PMID:  16504869     Owner:  NLM     Status:  MEDLINE    
The clinical behavior of central giant cell granuloma (CGCG) of the jaws is variable and difficult to predict. Clinical data and follow-up information of 26 patients with CGCG were analyzed. Histologic features were correlated with the clinical course of the disease. In 16 patients the CGCGs were asymptomatic; 10 lesions presented with aggressive growth, pain, massive swelling, root resorption, cortical perforation, and/or recurrence. These patients were younger and the lesions were larger than in the nonaggressive group. The histomorphometric analysis proved a significant increase in large giant cells, fractional surface area, and mitotic activity in aggressive CGCG lesions. Immunohistologic investigation (Ki-67 and p53 stain) revealed no significant differences. After surgical treatment, 3 patients with aggressive lesions developed a recurrence. The data show that clinical and histomorphometric features may be reliable indicators for the differentiation between aggressive and nonaggressive CGCG. This should be accounted for to improve the individual planning of the treatment and follow-up.
Birgit Kruse-Lösler; Raihanatou Diallo; Christoph Gaertner; Karl-Ludwig Mischke; Ulrich Joos; Johannes Kleinheinz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  101     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-28     Completed Date:  2006-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  346-54     Citation Subset:  D; IM    
Department of Craniomaxillofacial Surgery, University of Münster, Münster, Germany.
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MeSH Terms
Age Factors
Child, Preschool
Discriminant Analysis
Follow-Up Studies
Granuloma, Giant Cell / genetics,  pathology*,  radiography,  surgery
Jaw Diseases / genetics,  pathology*,  radiography,  surgery
Ki-67 Antigen / analysis
Middle Aged
Nucleic Acid Hybridization
Retrospective Studies
Sex Ratio
Tumor Suppressor Protein p53 / analysis
Reg. No./Substance:
0/Ki-67 Antigen; 0/Tumor Suppressor Protein p53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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