Document Detail


Central gastrin inhibits feeding behavior and food passage in neonatal chicks.
MedLine Citation:
PMID:  10447216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The gastrin/cholecystokinin (CCK) family is recognized as the principal family of hormones involved in regulation of the gastrointestinal tract CCK is recognized as a satiety hormone in mammalian species, but it has been suggested that gastrin rather CCK may have an important role in controlling feeding behavior in the neonatal chick through a poorly developed blood brain barrier. So far, however, there is no direct evidence that central gastrin inhibits food intake in neonatal chicks. The aim of this study was to elucidate whether central administration of gastrin 1) inhibits feeding behavior and 2) alters food passage from the crop. The effects of central administration of gastrin on food intake were investigated in experiment 1. Birds (2-day-old) were food-deprived for 3 h and then gastrin or saline was injected intracerebroventricularly. Gastrin strongly inhibited food intake in a dose-dependent fashion for 2 h. Thereafter, the effects of central gastrin on feeding behavior and serum corticosterone concentration were examined in experiment 2. Following central administration of gastrin, food intake was depressed and pecking behavior was inhibited. Serum corticosterone concentration was not altered by central administration of gastrin. The influence of central gastrin on food passage from the crop was investigated in experiment 3. Central administration of gastrin clearly delayed food passage. In conclusion, central gastrin appears to have a strong effect for the satiety and gastrointestinal motility in the neonatal chick.
Authors:
M Furuse; R Ao; T Bungo; R Ando; M Shimojo; Y Masuda; N Saito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  65     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1999  
Date Detail:
Created Date:  1999-08-27     Completed Date:  1999-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  305-11     Citation Subset:  IM    
Affiliation:
Laboratory of Animal Feed Science, Faculty of Agriculture, Kyushu University, Fukuoka, Japan. furuse@agr.kyushu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Chickens
Dose-Response Relationship, Drug
Drinking / drug effects
Eating / drug effects
Feeding Behavior / drug effects*
Gastric Emptying / drug effects
Gastrins / administration & dosage,  pharmacology,  physiology*
Gastrointestinal Transit / drug effects*
Injections, Intraventricular
Male
Motor Activity / drug effects
Chemical
Reg. No./Substance:
0/Gastrins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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