Document Detail


Central galanin and N-terminal galanin fragment induce c-Fos immunoreactivity in the medulla oblongata of the anesthetized rat.
MedLine Citation:
PMID:  11514035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This immunohistochemical study analyzed the c-Fos expression (c-Fos-ir) induced by galanin injections. Galanin and N-terminal galanin fragment (1-15) induced a significant increase of c-Fos expression (c-ir) within the medulla oblongata 90 min and 6 h. after intracisternal injections. This expression has been studied mainly in the nucleus of the solitary tract and in the ventrolateral medulla showing different temporal profiles for both peptides. The presence of c-Fos-ir in TH-positive cells was analyzed in all the groups. These results may be relevant to understand the role of galanin in several functions including central cardiovascular control.
Authors:
P Marcos; Z Díaz-Cabiale; M P Cordón; R Coveñas; N Yanaihara; K Fuxe; S González-Barón; J A Narváez
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  22     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-21     Completed Date:  2001-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1501-9     Citation Subset:  IM    
Affiliation:
Departamento de Fisiología, Facultad de Medicina, Campus de Teatinos s/n, 29080, Málaga, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Count
Galanin / pharmacology*
Glial Fibrillary Acidic Protein / immunology
Immunohistochemistry
Male
Medulla Oblongata / drug effects,  enzymology,  metabolism*
Neuroglia / immunology
Neurons / immunology,  metabolism
Peptide Fragments / pharmacology*
Proto-Oncogene Proteins c-fos / immunology,  metabolism*
Rabbits
Rats
Rats, Sprague-Dawley
Solitary Nucleus / cytology,  drug effects,  enzymology,  metabolism*
Specific Pathogen-Free Organisms
Time Factors
Tyrosine 3-Monooxygenase / immunology,  metabolism*
Chemical
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; 0/Peptide Fragments; 0/Proto-Oncogene Proteins c-fos; 88813-36-9/Galanin; EC 1.14.16.2/Tyrosine 3-Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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