Document Detail

Central enhancement of taste pleasure by intraventricular morphine.
MedLine Citation:
PMID:  8696295     Owner:  NLM     Status:  MEDLINE    
Do centrally-administered opioid agonists stimulate feeding by enhancing the palatability of foods? This hypothesis has been supported by several lines of evidence, including previous 'taste reactivity' studies of the influence of systemic morphine on affective (hedonic and aversive) behavioral reactions to taste palatability. The presents study examined whether opioid agonists enhance palatability by acting centrally on brain palatability systems. Here we report the effect of intraventricular microinjections of morphine (0, 12, 25, 50 nmols) on hedonic taste reactions to a 0.12 M sucrose solution. The effect on feeding was also assessed in order to determine whether feeding and palatability enhancement are linked, as would be required by the hypothesis that feeding is due to enhanced palatability. Both hedonic taste reactivity patterns and feeding were significantly increased together by morphine administration into the lateral ventricle. We conclude that opioid-induced enhancement of the hedonic palatability of food is a centrally mediated effect. Enhancement of food palatability may be an important psychological route by which intracranial administration of opioid agonists induce feeding.
S Peciña; K C Berridge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurobiology (Budapest, Hungary)     Volume:  3     ISSN:  1216-8068     ISO Abbreviation:  Neurobiology (Bp)     Publication Date:  1995  
Date Detail:
Created Date:  1996-09-05     Completed Date:  1996-09-05     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9312159     Medline TA:  Neurobiology (Bp)     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  269-80     Citation Subset:  IM    
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MeSH Terms
Feeding Behavior / drug effects*
Injections, Intraventricular
Morphine / pharmacology*
Narcotics / pharmacology*
Rats, Sprague-Dawley
Taste / drug effects*
Reg. No./Substance:
0/Narcotics; 76I7G6D29C/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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