| Central effects of mineralocorticoid antagonist RU-28318 on blood pressure of DOCA-salt hypertensive rats. | |
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MedLine Citation:
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PMID: 7810636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of brain mineralocorticoid receptor (MR) sites in the pathogenesis of mineralocorticoid hypertension was studied after an intracerebroventricular injection of the MR antagonist RU-28318. Male Wistar rats received subcutaneously implanted deoxycorticosterone acetate (DOCA) pellets and were maintained on 0.9% saline as drinking solution. Under these conditions hypertension developed in approximately 5 wk as assessed in conscious rats by means of the tail-cuff technique. During the development of this hypertension (after 3 wk of DOCA-salt treatment) a single intracerebroventricular injection of the specific MR antagonist RU-28318 reduced systolic blood pressure (SBP) as measured with the tail-cuff method. A decrease in SBP was observed 2-24 h after this intracerebroventricular injection, with the lowest SBP values occurring at 8 h. In these animals (3 wk after DOCA implantation) continuous direct blood pressure recording via chronic cannulation revealed, on the day of the intracerebroventricular injection of RU-28318, a slight increase in arterial pressure during the light phase, followed by a decrease during the dark phase. In the established hypertensive rats (5 wk after DOCA RU-28318 on the arterial pressure or heart rate was detectable. It is concluded that central MR blockade during the development of the DOCA-salt hypertension reduces blood pressure within 24 h assessed with 1) the indirect method at certain time points after exposure to warming and stress and 2) the direct method during the dark phase of the diurnal cycle. |
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Authors:
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D T Van den Berg; E R de Kloet; W de Jong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 267 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-01-31 Completed Date: 1995-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E927-33 Citation Subset: IM |
Affiliation:
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Leiden/Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone Antagonists
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pharmacology* Animals Blood Pressure / drug effects* Brain / drug effects* Desoxycorticosterone Heart Rate / drug effects Hypertension / physiopathology* Male Rats Rats, Wistar Receptors, Mineralocorticoid / antagonists & inhibitors*, physiology Sodium Chloride Spironolactone / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Receptors, Mineralocorticoid; 52-01-7/Spironolactone; 64-85-7/Desoxycorticosterone; 7647-14-5/Sodium Chloride; 76676-34-1/RU 28318 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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