Document Detail

Central effects of calcitonin receptor-stimulating peptide-1 on energy homeostasis in rats.
MedLine Citation:
PMID:  16410305     Owner:  NLM     Status:  MEDLINE    
The CT-R [calcitonin (CT) receptor] is expressed in the central nervous system and is involved in the regulation of food intake, thermogenesis, and behaviors. CT-R-stimulating peptide-1 (CRSP-1), a potent ligand for the CT-R, was recently isolated from the porcine brain. In this study, we first confirmed that porcine CRSP-1 (pCRSP-1) enhanced the cAMP production in COS-7 cells expressing recombinant rat CT-R, and then we examined the central effects of pCRSP-1 on feeding and energy homeostasis in rats. Intracerebroventricular (icv) administration of pCRSP-1 to free-feeding rats suppressed food intake in a dose-dependent manner. Chronic icv infusion of pCRSP-1 suppressed body weight gain over the infusion period. Furthermore, icv administration of pCRSP-1 increased body temperature and decreased locomotor activity. The central effects of pCRSP-1 were more potent than those of porcine CT in rats. In contrast, ip administration of pCRSP-1 did not elicit any anorectic or catabolic effects. Administration icv of pCRSP-1 also induced mild dyskinesia of the lower extremities and decreased gastric acid output. Fos expression induced by icv administration of pCRSP-1 was detected in the neurons of the paraventricular nucleus, dorsomedial hypothalamic nucleus, arcuate nucleus, locus coeruleus, and nucleus of solitary tract, areas that are known to regulate feeding and energy homeostasis. Administration icv of pCRSP-1 increased plasma concentrations of ACTH and corticosterone, implying that the hypothalamic-pituitary-adrenocortical axis might be involved in catabolic effects of pCRSP-1. These results suggest that CRSP-1 can function as a ligand for the CT-R and may act as a catabolic signaling molecule in the central nervous system.
Hirotake Sawada; Hideki Yamaguchi; Takuya Shimbara; Koji Toshinai; Muhtashan S Mondal; Yukari Date; Noboru Murakami; Takeshi Katafuchi; Naoto Minamino; Hiroyuki Nunoi; Masamitsu Nakazato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-12
Journal Detail:
Title:  Endocrinology     Volume:  147     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-17     Completed Date:  2006-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2043-50     Citation Subset:  AIM; IM    
Department of Pediatrics, Miyazaki Medical College, University of Miyazaki, Japan.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Body Temperature / drug effects
Brain / drug effects*
Calcitonin Gene-Related Peptide / pharmacology*
Corticosterone / blood
Eating / drug effects
Energy Metabolism / drug effects*
Homeostasis / drug effects
Motor Activity / drug effects
Rats, Wistar
Receptors, Calcitonin / agonists*
Weight Gain / drug effects
Reg. No./Substance:
0/Ligands; 0/Receptors, Calcitonin; 50-22-6/Corticosterone; 83652-28-2/Calcitonin Gene-Related Peptide; 9002-60-2/Adrenocorticotropic Hormone

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