Document Detail

Central effects of 5-HT on respiratory and hypoglossal activities in the adult cat.
MedLine Citation:
PMID:  8525122     Owner:  NLM     Status:  MEDLINE    
The activities of the diaphragmatic, internal intercostal and hypoglossal-innervated muscles were studied in adult decerebrate cats in response to 5-HT and related agents (8-OH-DPAT and DOI). The drugs were placed on the floor of the IVth ventricle. The mean respiratory frequency (Fi) increased (124-193% of the control value) within 3 min of the 5-HT application, and decreased thereafter (30-90%). The mean Ti and Te changed similarly, but opposite to Fi. With some delay, the hypoglossal-innervated muscles were tonically activated or exhibited increased activities. Methysergide pretreatment completely blocked the effect of 5-HT on all the respiratory parameters and the hypoglossal-innervated muscles activities. The responses to 8-OH-DPAT and DOI indicate that 5-HT modulates the respiratory frequency via activation of both 5-HT1A and 5-HT2 receptors. Nevertheless, the effect of 5-HT on both the expiratory and hypoglossal-innervated muscles seems to depend on 5-HT2 receptors activation only.
D Rose; J Khater-Boidin; P Toussaint; B Duron
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  101     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-01-24     Completed Date:  1996-01-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  59-69     Citation Subset:  IM    
Laboratoire de Neurophysiologie Clinique et Expérimentale, Ontogenèse des Systèmes Moteurs Intégres, URA 1331 CNRS, Amiens, France.
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MeSH Terms
Decerebrate State / physiopathology
Diaphragm / drug effects,  innervation,  physiology
Hypoglossal Nerve / drug effects*
Injections, Intraventricular
Respiratory Mechanics / drug effects*
Serotonin / administration & dosage,  pharmacology*
Serotonin Agonists / administration & dosage,  pharmacology*
Serotonin Antagonists / administration & dosage,  pharmacology
Reg. No./Substance:
0/Serotonin Agonists; 0/Serotonin Antagonists; 50-67-9/Serotonin

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