Document Detail

Central diabetes insipidus and inv(3)(q21q26) and monosomy 7 in acute myeloid leukemia.
MedLine Citation:
PMID:  12165457     Owner:  NLM     Status:  MEDLINE    
Chromosomal anomalies involving region 3q21q26 have been reported associated with thrombocytosis in various hematological malignancies, such as chronic myeloid leukemia, myelodysplastic syndrome, and acute myeloid leukemia (AML). Recent reports described the association of central diabetes insipidus with AML and chromosomal anomalies involving region 3q21q26. We review the database in our institution and report five cases of inv(3)(q21q26) in consecutive cytogenetic studies of AML and myelodysplastic syndromes from 1992 to 2000, two cases presented as sole abnormalities and three cases were associated with monosomy 7. Only one case was associated with central diabetes insipidus. The literature of 3q21q26 syndrome and central diabetes insipidus in myeloid leukemia is reviewed.
Yi-Kong Keung; David Buss; Bayard L Powell; Mark Pettenati
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  136     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-08-07     Completed Date:  2002-08-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  78-81     Citation Subset:  IM    
Section on Hematology and Oncology, Comprehensive Cancer Center, Wake Forest University, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
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MeSH Terms
Chromosome Inversion*
Chromosomes, Human, Pair 3*
Chromosomes, Human, Pair 7*
Diabetes Insipidus, Neurogenic / genetics*
Leukemia, Myeloid, Acute / genetics*
Middle Aged

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