Document Detail

Central corneal thickness as a predictor of visual field loss in primary open angle glaucoma for a Hispanic population.
MedLine Citation:
PMID:  21275602     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Primary Open Angle Glaucoma is a multi-factorial disease with a devastating impact on the quality of life of the patient in the moderate and severe stages of the disease. Identifying risk factors for the development of moderate to severe visual field loss may decrease the proportion of patients that experience the severe forms of this disease.
PURPOSE: To evaluate whether the central corneal thickness correlates inversely with the severity of visual field loss in Primary Open Angle Glaucoma.
METHODS: Retrospective review of 308 charts of patients seen during a six-week period by a glaucoma specialist in his community practice in a large Hispanic area. Patients were classified as normal, ocular hypertensive, and those with Primary Open Angle Glaucoma. Odds ratios and 95% confidence interval were calculated to evaluate risk factors associated to ocular hypertension and Primary Open Angle Glaucoma. Finally, a multivariate polytomous regression model was used to evaluate central corneal thickness as an independent predictor of outcome after adjustment for age and hypertension. Statistical significance was set at p<0.05.
RESULTS: Patients with Primary Open Angle Glaucoma show a statistically significant inverse correlation between central corneal thickness and the severity of the visual field damage.
CONCLUSION: Thinner corneas could be considered a risk factor for the severity of visual field loss in Primary Open Angle Glaucoma.
Jorge L Fernandez-Bahamonde; Christian Roman-Rodriguez; Maria C Fernandez-Ruiz
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Seminars in ophthalmology     Volume:  26     ISSN:  1744-5205     ISO Abbreviation:  Semin Ophthalmol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-05-17     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8610759     Medline TA:  Semin Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  28-32     Citation Subset:  IM    
Ophthalmology Department, University of Puerto Rico School of Medicine, PO Box 194507, San Juan PR 00919-4507.
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MeSH Terms
Aged, 80 and over
Cornea / pathology*
Glaucoma, Open-Angle / diagnosis*,  ethnology
Hispanic Americans / ethnology
Intraocular Pressure
Middle Aged
Ocular Hypertension / diagnosis,  ethnology
Odds Ratio
Puerto Rico / epidemiology
Retrospective Studies
Risk Factors
Tonometry, Ocular
Vision Disorders / diagnosis*,  ethnology
Visual Fields*
Grant Support
P20 RR11126/RR/NCRR NIH HHS; U54 RR026139-01A1/RR/NCRR NIH HHS

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