Document Detail


Central control of thermogenesis in mammals.
MedLine Citation:
PMID:  18469069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thermogenesis, the production of heat energy, is an essential component of the homeostatic repertoire to maintain body temperature in mammals and birds during the challenge of low environmental temperature and plays a key role in elevating body temperature during the febrile response to infection. The primary sources of neurally regulated metabolic heat production are mitochondrial oxidation in brown adipose tissue, increases in heart rate and shivering in skeletal muscle. Thermogenesis is regulated in each of these tissues by parallel networks in the central nervous system, which respond to feedforward afferent signals from cutaneous and core body thermoreceptors and to feedback signals from brain thermosensitive neurons to activate the appropriate sympathetic and somatic efferents. This review summarizes the research leading to a model of the feedforward reflex pathway through which environmental cold stimulates thermogenesis and discusses the influence on this thermoregulatory network of the pyrogenic mediator, prostaglandin E(2), to increase body temperature. The cold thermal afferent circuit from cutaneous thermal receptors ascends via second-order thermosensory neurons in the dorsal horn of the spinal cord to activate neurons in the lateral parabrachial nucleus, which drive GABAergic interneurons in the preoptic area to inhibit warm-sensitive, inhibitory output neurons of the preoptic area. The resulting disinhibition of thermogenesis-promoting neurons in the dorsomedial hypothalamus and possibly of sympathetic and somatic premotor neurons in the rostral ventromedial medulla, including the raphe pallidus, activates excitatory inputs to spinal sympathetic and somatic motor circuits to drive thermogenesis.
Authors:
Shaun F Morrison; Kazuhiro Nakamura; Christopher J Madden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-05-09
Journal Detail:
Title:  Experimental physiology     Volume:  93     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-19     Completed Date:  2008-09-25     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  773-97     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature Regulation / physiology*
Heart Rate / physiology
Homeostasis / physiology*
Humans
Oxidation-Reduction
Shivering / physiology
Thermogenesis / physiology*
Thermoreceptors / physiology
Grant Support
ID/Acronym/Agency:
DK57838/DK/NIDDK NIH HHS; DK65401/DK/NIDDK NIH HHS; F32 DK065401-02/DK/NIDDK NIH HHS; F32 DK065401-03/DK/NIDDK NIH HHS; NS40987/NS/NINDS NIH HHS; R01 DK057838/DK/NIDDK NIH HHS; R01 DK057838-06/DK/NIDDK NIH HHS; R01 DK057838-07/DK/NIDDK NIH HHS; R01 DK057838-08/DK/NIDDK NIH HHS; R01 NS040987/NS/NINDS NIH HHS; R01 NS040987-06/NS/NINDS NIH HHS; R01 NS040987-07/NS/NINDS NIH HHS; R01 NS040987-08/NS/NINDS NIH HHS
Comments/Corrections

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