Document Detail


Central control mechanisms in hypertension.
MedLine Citation:
PMID:  9448900     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is substantial evidence for an activation of the sympathetic nervous system in man as well as in genetic models of hypertension, such as the spontaneously hypertensive rat (SHR), but we are only beginning to understand the central mechanisms that generate changes in sympathetic activity and elevate blood pressure (BP). Significant recent advances have been made in defining the neural pathways involved in BP regulation and in identifying the neurotransmitters these neurones utilise. In this overview, we describe the neural pathways within the medulla oblongata and spinal cord that participate in BP control and examine the role of amino acid neurotransmitters within these pathways. We demonstrate how alterations in these pathways explain the sympathetic activation observed in the SHR and contribute to hypertension in this model. Lastly, we examine the application of modern molecular biological approaches to further our understanding of the neural regulation of the circulation. In these studies, we used the administration of antisense oligonucleotides to interrupt gene expression.
Authors:
L Arnolda; H H Wang; J Minson; I Llewellyn-Smith; S Suzuki; P Pilowsky; J Chalmers
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Australian and New Zealand journal of medicine     Volume:  27     ISSN:  0004-8291     ISO Abbreviation:  Aust N Z J Med     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1998-03-18     Completed Date:  1998-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1264322     Medline TA:  Aust N Z J Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  474-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Flinders University of South Australia, Adelaide.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Disease Models, Animal
Female
Gene Expression
Humans
Hypertension / genetics,  metabolism,  physiopathology*
Male
Neural Pathways / physiopathology
Neurotransmitter Agents / genetics,  metabolism
Rats
Signal Transduction
Sympathetic Nervous System / metabolism,  physiopathology*
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents

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