Document Detail

Central control mechanisms in hypertension.
MedLine Citation:
PMID:  9448900     Owner:  NLM     Status:  MEDLINE    
There is substantial evidence for an activation of the sympathetic nervous system in man as well as in genetic models of hypertension, such as the spontaneously hypertensive rat (SHR), but we are only beginning to understand the central mechanisms that generate changes in sympathetic activity and elevate blood pressure (BP). Significant recent advances have been made in defining the neural pathways involved in BP regulation and in identifying the neurotransmitters these neurones utilise. In this overview, we describe the neural pathways within the medulla oblongata and spinal cord that participate in BP control and examine the role of amino acid neurotransmitters within these pathways. We demonstrate how alterations in these pathways explain the sympathetic activation observed in the SHR and contribute to hypertension in this model. Lastly, we examine the application of modern molecular biological approaches to further our understanding of the neural regulation of the circulation. In these studies, we used the administration of antisense oligonucleotides to interrupt gene expression.
L Arnolda; H H Wang; J Minson; I Llewellyn-Smith; S Suzuki; P Pilowsky; J Chalmers
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Australian and New Zealand journal of medicine     Volume:  27     ISSN:  0004-8291     ISO Abbreviation:  Aust N Z J Med     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1998-03-18     Completed Date:  1998-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1264322     Medline TA:  Aust N Z J Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  474-8     Citation Subset:  IM    
Department of Medicine, Flinders University of South Australia, Adelaide.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure
Disease Models, Animal
Gene Expression
Hypertension / genetics,  metabolism,  physiopathology*
Neural Pathways / physiopathology
Neurotransmitter Agents / genetics,  metabolism
Signal Transduction
Sympathetic Nervous System / metabolism,  physiopathology*
Reg. No./Substance:
0/Neurotransmitter Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The importance of the autonomic nervous system in health and disease.
Next Document:  Spinal cord excitatory amino acid receptors and plasma catecholamine autonomic responses in the cons...