| Central cholinergic modulation of blood pressure short-term variability. | |
| | |
MedLine Citation:
|
PMID: 16487550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of neurally born acetylcholine in the central modulation of cardiovascular short-term variability was assessed using a pharmacological probe physostigmine, a cholinesterase inhibitor that can act centrally also. Experiments were performed in instrumented conscious rats. Equidistant sampling at 20 Hz of systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and heart rate (HR) allowed direct spectral analysis. Spectra were analysed in the whole, very-low frequency (VLF), low-frequency (LF) and high-frequency (HF) domains. Physostigmine, but not neostigmine, increased SAP, LF SAP and HF SAP variability while neostigmine, but not physostigmine, decreased HR without affecting HR variability. Atropine methyl nitrate prevented neostigmine-induced bradycardia and potentiated the effects of physostigmine on DAP, LF DAP and HF DAP variability. Atropine sulphate, hexamethonium, phentolamine and metoprolol inhibited physostigmine-induced increase of SAP and LF SAP. Pre-treatment of rats by quinapril prevented physostigmine-induced increase of SAP, but not of LF SAP, while the V(1a) antagonist prevented the increase of HF SAP. The results suggest that central cholinergic neurons facilitate but do not create LF SAP and HF SAP variability. The effect of physostigmine on LF SAP seems to be mediated via central muscarinic sites and the peripheral sympathetic system, while non-muscarinic central sites and vasopressin pathways subserve the increase of HF SAP. |
| | |
Authors:
|
Sanja Milutinović; David Murphy; Nina Japundzić-Zigon |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-02-17 |
Journal Detail:
|
Title: Neuropharmacology Volume: 50 ISSN: 0028-3908 ISO Abbreviation: Neuropharmacology Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-05-26 Completed Date: 2006-10-06 Revised Date: 2007-08-13 |
Medline Journal Info:
|
Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: England |
Other Details:
|
Languages: eng Pagination: 874-83 Citation Subset: IM |
Affiliation:
|
Laboratory for Cardiovascular Pharmacology, Institute of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, P.O. Box 840, 11129 Belgrade, Serbia and Montenegro. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects, physiology* Cholinergic Agents / pharmacology Cholinergic Fibers / drug effects, physiology* Cholinesterase Inhibitors / pharmacology* Heart Rate / drug effects, physiology Male Physostigmine / pharmacology Rats Rats, Wistar Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
0/Cholinergic Agents; 0/Cholinesterase Inhibitors; 57-47-6/Physostigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The number distribution for involved lymph nodes in cancer.
Next Document: A health evaluation in a colony of captive collared peccaries (Tayassu tajacu) in the Eastern Amazon...