Document Detail

Central cholinergic mechanisms mediate swallowing, renal excretion, and c-fos expression in the ovine fetus near term.
MedLine Citation:
PMID:  19005017     Owner:  NLM     Status:  MEDLINE    
Fetal swallowing and renal metabolism contribute importantly to amniotic and body fluid homeostasis. To determine central cholinergic modulation of swallowing activity and renal excretion associated with neural activity, we examined the effects of intracerebroventricular injection of carbachol, a cholinergic agonist, in ovine fetuses at 0.9 gestation. Fetuses were chronically prepared with thyrohyoid, nuchal and thoracic esophagus, and diaphragm electromyogram electrodes, as well as lateral ventricle and vascular catheters. Electrodes were also implanted on the parietal dura for determination of fetal electrocorticogram (ECoG). After 5 days of recovery, fetal swallowing, ECoG, and urine output were monitored during basal period and the experimental period following intracerebroventricular injection of 0.9% NaCl as the control (n = 5) or carbachol (3 microg/kg, n = 5). Central carbachol did not significantly change fetal low voltage (LV) and high voltage (HV) ECoG temporal distributions. However, swallowing activity during LV ECoG was elevated significantly after intracerebroventricular carbachol. Associated with the swallowing activation, c-fos immunoreactivity in the putative dipsogenic center, subfornical organ, was enhanced significantly. The fetal urine flow rate and renal Na+, K+, and Cl(-) excretion were markedly increased following intracerebroventricular carbachol and sustained at the high level for at least 2 h. The results indicate that the central cholinergic mechanism is established and functional in regulation of fetal behavior and renal excretion at least at 0.9 gestation, which plays an important role in maintenance of fetal body fluid homeostasis.
Lijun Shi; Caiping Mao; Fanxing Zeng; Liyan Zhu; Zhice Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-12
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  296     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R318-25     Citation Subset:  IM    
Department of Human Sport Science, Beijing Sport University, Beijing, China.
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MeSH Terms
Carbachol / administration & dosage
Chlorides / urine
Cholinergic Agonists / administration & dosage
Cholinergic Fibers / drug effects,  metabolism*
Deglutition* / drug effects
Esophagus / drug effects,  embryology,  innervation*
Gestational Age
Injections, Intraventricular
Kidney / drug effects,  embryology,  innervation*
Potassium / urine
Proto-Oncogene Proteins c-fos / metabolism*
Sodium / urine
Subfornical Organ / drug effects,  embryology,  metabolism*
Time Factors
Water-Electrolyte Balance* / drug effects
Reg. No./Substance:
0/Chlorides; 0/Cholinergic Agonists; 0/Proto-Oncogene Proteins c-fos; 51-83-2/Carbachol; 7440-09-7/Potassium; 7440-23-5/Sodium

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