| Central cholinergic mechanisms mediate swallowing, renal excretion, and c-fos expression in the ovine fetus near term. | |
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MedLine Citation:
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PMID: 19005017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fetal swallowing and renal metabolism contribute importantly to amniotic and body fluid homeostasis. To determine central cholinergic modulation of swallowing activity and renal excretion associated with neural activity, we examined the effects of intracerebroventricular injection of carbachol, a cholinergic agonist, in ovine fetuses at 0.9 gestation. Fetuses were chronically prepared with thyrohyoid, nuchal and thoracic esophagus, and diaphragm electromyogram electrodes, as well as lateral ventricle and vascular catheters. Electrodes were also implanted on the parietal dura for determination of fetal electrocorticogram (ECoG). After 5 days of recovery, fetal swallowing, ECoG, and urine output were monitored during basal period and the experimental period following intracerebroventricular injection of 0.9% NaCl as the control (n = 5) or carbachol (3 microg/kg, n = 5). Central carbachol did not significantly change fetal low voltage (LV) and high voltage (HV) ECoG temporal distributions. However, swallowing activity during LV ECoG was elevated significantly after intracerebroventricular carbachol. Associated with the swallowing activation, c-fos immunoreactivity in the putative dipsogenic center, subfornical organ, was enhanced significantly. The fetal urine flow rate and renal Na+, K+, and Cl(-) excretion were markedly increased following intracerebroventricular carbachol and sustained at the high level for at least 2 h. The results indicate that the central cholinergic mechanism is established and functional in regulation of fetal behavior and renal excretion at least at 0.9 gestation, which plays an important role in maintenance of fetal body fluid homeostasis. |
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Authors:
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Lijun Shi; Caiping Mao; Fanxing Zeng; Liyan Zhu; Zhice Xu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-12 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 296 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-27 Completed Date: 2009-03-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R318-25 Citation Subset: IM |
Affiliation:
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Department of Human Sport Science, Beijing Sport University, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbachol / administration & dosage Chlorides / urine Cholinergic Agonists / administration & dosage Cholinergic Fibers / drug effects, metabolism* Deglutition* / drug effects Diuresis Electroencephalography Electromyography Esophagus / drug effects, embryology, innervation* Female Gestational Age Homeostasis Injections, Intraventricular Kidney / drug effects, embryology, innervation* Natriuresis Potassium / urine Pregnancy Proto-Oncogene Proteins c-fos / metabolism* Sheep Sodium / urine Subfornical Organ / drug effects, embryology, metabolism* Time Factors Urodynamics Water-Electrolyte Balance* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 0/Cholinergic Agonists; 0/Proto-Oncogene Proteins c-fos; 51-83-2/Carbachol; 7440-09-7/Potassium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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