Document Detail


Central catecholamine depletion, vasopressin, and blood pressure in the DOCA/NaCl rat.
MedLine Citation:
PMID:  6407335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine whether impaired arginine vasopressin (AVP) release occurs when DOCA-NaCl hypertension is prevented following chemical sympathectomy with 6-hydroxydopamine (6-OHDA), male Sprague-Dawley rats treated with intraventricular injections of 6-OHDA (250 micrograms X 2) or Merlis solution received deoxycorticosterone acetate (DOCA) implants (100 mg/kg) and drank 0.5% saline. Systolic blood pressure in the 6-OHDA-treated DOCA/NaCl group (139 +/- 4 mmHg) was lower (P less than 0.001) than in the Merlis-DOCA/NaCl group (183 +/- 7 mmHg). 6-OHDA treatment produced widespread catecholamine depletion throughout the central nervous system, including the supraoptic and paraventricular nuclei, the cells of which are known to produce AVP, but hypothalamic, pituitary, and plasma AVP levels were similar in both experimental groups, the latter values averaging 1.5-2 times those of controls. Both groups of rats suppressed AVP secretion appropriately when water loaded. Such suppression, however, had no effect on blood pressure in the hypertensive animals and, furthermore, administration of the AVP antagonist d(CH2)5Tyr(Me)AVP produced small decrements in mean blood pressure of both groups that were not significantly different from responses seen in control normotensive rats. These data demonstrate that 6-OHDA does not prevent DOCA-NaCl hypertension by decreasing AVP levels and suggest that AVP is not necessary for the maintenance of hypertension in this model.
Authors:
T Okuno; S R Winternitz; M D Lindheimer; S Oparil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  244     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-07-29     Completed Date:  1983-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H807-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine Vasopressin / secretion*
Blood Pressure / drug effects*
Brain / drug effects,  metabolism*
Desoxycorticosterone / pharmacology*
Dopamine / metabolism*
Hydroxydopamines
Kinetics
Male
Norepinephrine / metabolism*
Oxidopamine
Rats
Rats, Inbred Strains
Sodium Chloride / pharmacology*
Spinal Cord / drug effects,  metabolism*
Sympathectomy, Chemical
Grant Support
ID/Acronym/Agency:
HD-5572/HD/NICHD NIH HHS; HL-22544/HL/NHLBI NIH HHS; HL-25451/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hydroxydopamines; 113-79-1/Arginine Vasopressin; 1199-18-4/Oxidopamine; 51-41-2/Norepinephrine; 64-85-7/Desoxycorticosterone; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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