| Central cardiovascular and thermal effects of prostaglandin D2 in rats. | |
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MedLine Citation:
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PMID: 6955803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostaglandin D2 (PGD2) is the most common prostaglandin type of the rat brain. Recently a neuromodulator role for PGD2 has been suggested. In the present work the central cardiovascular and thermal effects of PGD2 were studied in urethane-anaesthetised rats. When administered at the doses of 0.001-10 micrograms/rat into the lateral cerebral ventricle (i.c.v.), PGD2 slightly increased the blood pressure, heart rate and body temperature. The highest dose caused also an initial hypotensive effect. Upon intravenous injections PGD2 (0.1-10 micrograms/rat) initially decreased and then weakly increased the blood pressure but had only negligible effects on heart rate and body temperature. Central pretreatment with sodium meclofenamate or indomethacin (1 mg/rat i.c.v.) antagonised effectively all the recorded central effects of PGD2. The central cardiovascular and thermal effects of PGD2 were much weaker than those obtained earlier with other prostaglandins, such as PGF2 alpha and PGE2. Therefore, in spite of its abundance in the brain PGD2 may not be very important for the central cardiovascular and thermal regulation in the rat. |
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Authors:
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A L Sirén |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and medicine Volume: 8 ISSN: 0262-1746 ISO Abbreviation: Prostaglandins Leukot Med Publication Date: 1982 Apr |
Date Detail:
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Created Date: 1982-10-21 Completed Date: 1982-10-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8206868 Medline TA: Prostaglandins Leukot Med Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 349-59 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Body Temperature / drug effects* Dose-Response Relationship, Drug Heart Rate / drug effects* Indomethacin / pharmacology Injections, Intravenous Injections, Intraventricular Male Meclofenamic Acid / pharmacology Prostaglandin D2 Prostaglandins / pharmacology* Prostaglandins D / administration & dosage, pharmacology* Rats Rats, Inbred Strains Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 0/Prostaglandins D; 41598-07-6/Prostaglandin D2; 53-86-1/Indomethacin; 644-62-2/Meclofenamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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