Document Detail

Central cardiovascular effects of AVP and ANP in normotensive and spontaneously hypertensive rats.
MedLine Citation:
PMID:  8188982     Owner:  NLM     Status:  MEDLINE    
The purpose of the present study was to compare influence of central arginine vasopressin (AVP) and of atrial natriuretic peptide (ANP) on control of arterial blood pressure (MAP) and heart rate (HR) in normotensive (WKY) and spontaneously hypertensive (SHR) rats. Three series of experiments were performed on 30 WKY and 30 SHR, chronically instrumented with guide tubes in the lateral ventricle (LV) and arterial and venous catheters. MAP and HR were monitored before and after i.v. injections of either vehicle or 1, 10 and 50 ng of AVP and 25, 125 and 500 ng of ANP. Sensitivity of cardiac component of baroreflex (CCB), expressed as a slope of the regression line was determined from relationships between systolic arterial pressure (SAP) and HR period (HRp) during phenylephrine (Phe)-induced hypertension and sodium nitroprusside (SN)-induced hypotension. CCB was measured before and after administration of either vehicle, AVP, ANP, or both peptides together. Increases of MAP occurred after LV administration of 1, 10 and 50 ng of AVP in WKY and of 10 and 50 ng in SHR. ANP did not cause significant changes in MAP in both strains as compared to vehicle, but it abolished AVP-induced MAP increase in WKY and SHR. CCB was reduced in WKY and SHR after LV administration of AVP during SN-induced hypotension. In SHR but not in WKY administration of ANP, AVP and ANP + AVP decreased CCB during Phe-induced MAP elevation. The results indicate that centrally applied AVP and ANP exert differential effects on blood pressure and baroreflex control of heart rate in WKY and SHR and suggest interaction of these two peptides in blood pressure regulation at the level of central nervous system.
K Stepniakowski; A Budzikowski; S Loń; E Szczepańska-Sadowska
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  47     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-06-20     Completed Date:  1994-06-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  33-43     Citation Subset:  IM    
Department of Hypertension, Medical Academy of Warsaw, Poland.
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MeSH Terms
Arginine Vasopressin / administration & dosage,  antagonists & inhibitors,  pharmacology*
Atrial Natriuretic Factor / administration & dosage,  pharmacology*
Baroreflex / drug effects
Blood Pressure / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / physiopathology*
Injections, Intravenous
Injections, Intraventricular
Nitroprusside / pharmacology
Rats, Inbred SHR
Rats, Inbred WKY
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 15078-28-1/Nitroprusside; 85637-73-6/Atrial Natriuretic Factor

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