Document Detail


Central carbon metabolism of Leishmania parasites.
MedLine Citation:
PMID:  20158936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leishmania spp. are sandfly-transmitted protozoa parasites that cause a spectrum of diseases in humans. Many enzymes involved in Leishmania central carbon metabolism differ from their equivalents in the mammalian host and are potential drug targets. In this review we summarize recent advances in our understanding of Leishmania central carbon metabolism, focusing on pathways of carbon utilization that are required for growth and pathogenesis in the mammalian host. While Leishmania central carbon metabolism shares many features in common with other pathogenic trypanosomatids, significant differences are also apparent. Leishmania parasites are also unusual in constitutively expressing most core metabolic pathways throughout their life cycle, a feature that may allow these parasites to exploit a range of different carbon sources (primarily sugars and amino acids) rapidly in both the insect vector and vertebrate host. Indeed, recent gene deletion studies suggest that mammal-infective stages are dependent on multiple carbon sources in vivo. The application of metabolomic approaches, outlined here, are likely to be important in defining aspects of central carbon metabolism that are essential at different stages of mammalian host infection.
Authors:
Eleanor C Saunders; David P DE Souza; Thomas Naderer; Marijke F Sernee; Julie E Ralton; Maria A Doyle; James I Macrae; Jenny L Chambers; Joanne Heng; Amsha Nahid; Vladimir A Likic; Malcolm J McConville
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-02-17
Journal Detail:
Title:  Parasitology     Volume:  137     ISSN:  1469-8161     ISO Abbreviation:  Parasitology     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-06     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401121     Medline TA:  Parasitology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1303-13     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, University of Melbourne, 30 Flemington Rd, Parkville, 3010, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbohydrate Metabolism
Carbon / metabolism*
Host-Parasite Interactions
Humans
Intracellular Space / metabolism
Leishmania / growth & development,  metabolism*
Leishmaniasis / parasitology*
Life Cycle Stages
Mitochondria / metabolism
Parasites / metabolism
Chemical
Reg. No./Substance:
7440-44-0/Carbon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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