Document Detail


Central, but not basolateral, amygdala is critical for control of feeding by aversive learned cues.
MedLine Citation:
PMID:  19955373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Environmental factors contribute to the motivation to eat and can override homeostatic signals to stimulate eating in sated states, or inhibit eating in states of hunger. In particular, stress, fear, and anxiety have been linked to suppression of eating and anorexia nervosa. Here, we use a rodent model of an aversive cue-induced cessation of feeding. In this setting, food-deprived rats suppress eating when presented with a tone [conditioned stimulus (CS)] that was previously paired with footshocks [unconditioned stimulus (US)]. To begin to delineate the underlying neural circuitry we examined the two regions of the amygdala with well known roles in associative learning--the central nucleus (CEA) and the basolateral area (BLA; includes the basolateral, basomedial, and lateral nuclei). We produced selective, bilateral, neurotoxic lesions of the CEA or BLA, and then trained these rats together with sham-lesioned controls in a behavioral protocol that allowed a test for food consumption in the presence of an aversive CS. Both sham- and BLA-lesioned rats showed inhibition of eating when presented with the CS. In contrast, bilateral, neurotoxic lesions of the CEA abolished this effect. These results demonstrate that the CEA, but not BLA, is critical for control of feeding by an aversive CS. Previously we demonstrated that enhancement of eating by an appetitive CS is dependent on the integrity of BLA, but not CEA. Those findings together with the current results show a double dissociation between amygdalar subsystems that control food consumption by appetitive and aversive learned cues.
Authors:
Gorica D Petrovich; Cali A Ross; Pari Mody; Peter C Holland; Michela Gallagher
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  29     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-03     Completed Date:  2009-12-22     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15205-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amygdala / anatomy & histology*,  injuries,  physiology*
Analysis of Variance
Animals
Avoidance Learning / physiology*
Behavior, Animal
Brain Mapping
Conditioning, Classical
Cues*
Eating / drug effects
Electroshock
Excitatory Amino Acid Agonists / toxicity
Extinction, Psychological / physiology
Feeding Behavior / physiology*
Food Deprivation
Freezing Reaction, Cataleptic / physiology
Male
N-Methylaspartate / toxicity
Rats
Rats, Long-Evans
Grant Support
ID/Acronym/Agency:
K01 MH067252/MH/NIMH NIH HHS; K01 MH067252-05/MH/NIMH NIH HHS; MH60179/MH/NIMH NIH HHS; MH67252/MH/NIMH NIH HHS; R01 MH060179/MH/NIMH NIH HHS; R01 MH060179-09/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Excitatory Amino Acid Agonists; 6384-92-5/N-Methylaspartate
Comments/Corrections

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