Document Detail


Central bombesin activates adrenal adrenaline- and noradrenaline-containing cells via brain thromboxane A2 in rats.
MedLine Citation:
PMID:  19179117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sympathetic nervous system regulates peripheral organs via the adrenal chromaffin cells containing adrenaline (A-cells) or noradrenaline (NA-cells) and the sympathetic ganglia. We examined the effect of intracerebroventricularly administered bombesin on neuronal activities of adrenal A-cells and NA-cells and several kinds of sympathetic ganglia (superior cervical, stellate and celiac ganglia) using c-Fos (a marker for neuronal activation), with regard to brain prostanoid, in anesthetized rats. Bombesin induced c-Fos in both adrenal A-cells and NA-cells, but not in any of the sympathetic ganglia. Central pretreatment with either indomethacin (a cyclooxygenase inhibitor) or furegrelate (a thromboxane A(2) synthase inhibitor) abolished all bombesin-induced responses. These results suggest that bombesin centrally activates adrenal A-cells and NA-cells by brain thromboxane A(2)-mediated mechanisms in rats.
Authors:
Daisuke Usui; Naoko Yamaguchi-Shima; Shoshiro Okada; Takahiro Shimizu; Hiroshi Wakiguchi; Kunihiko Yokotani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  147     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-21     Completed Date:  2009-06-26     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Medicine, Kochi University, Nankoku, Kochi 783-8505, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Medulla / cytology,  drug effects,  metabolism*
Animals
Autonomic Pathways / cytology,  drug effects,  metabolism
Biological Markers
Bombesin / metabolism*,  pharmacology
Brain / drug effects,  metabolism
Catecholamines / metabolism*,  secretion
Cyclooxygenase Inhibitors / pharmacology
Enzyme Inhibitors / pharmacology
Ganglia, Sympathetic / cytology,  drug effects,  metabolism*
Male
Neurons / drug effects,  metabolism*
Neurotransmitter Agents / pharmacology
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Wistar
Sympathetic Nervous System / cytology,  drug effects,  metabolism
Synaptic Transmission / drug effects,  physiology
Thromboxane A2 / metabolism*
Thromboxane-A Synthase / antagonists & inhibitors,  metabolism
Up-Regulation / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Catecholamines; 0/Cyclooxygenase Inhibitors; 0/Enzyme Inhibitors; 0/Neurotransmitter Agents; 0/Proto-Oncogene Proteins c-fos; 31362-50-2/Bombesin; 57576-52-0/Thromboxane A2; EC 5.3.99.5/Thromboxane-A Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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