| Central blood pressure measurements-an opportunity for efficacy and safety in drug development? | |
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MedLine Citation:
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PMID: 20729159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over a century of experience with brachial blood pressure has produced a substantial amount of information on the role of blood pressure as a factor in heart disease, stroke and kidney failure. Successful interventions lowering blood pressure and reducing damage to vital organs testify further to the importance of this vital sign. In recent years attempts to probe deeper into the value of knowledge of blood pressure levels closer to the heart (central blood pressures) suggest that noninvasive measurement of central aortic blood pressure may improve further efforts directed at both understanding drug benefit and uncovering potential drug safety issues. This commentary is a summary of a one-day meeting with the FDA in which the role of central blood pressure measurements as an adjunct to drug efficacy and safety were addressed. |
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Authors:
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Raymond R Townsend; Mary J Roman; Samer S Najjar; John R Cockcroft; Peter U Feig; Norman L Stockbridge |
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Publication Detail:
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Type: Editorial Date: 2010-08-21 |
Journal Detail:
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Title: Journal of the American Society of Hypertension : JASH Volume: 4 ISSN: 1933-1711 ISO Abbreviation: J Am Soc Hypertens Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-10-13 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101312518 Medline TA: J Am Soc Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 211-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Society of Hypertension. All rights reserved. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Blood Pressure Determination / methods* Carotid Arteries* Drug Discovery Humans Hypertension / diagnosis*, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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