Document Detail

Central blood pressure effects of guanylyl-imido-diphosphate and cyclic guanosine-monophosphate.
MedLine Citation:
PMID:  6248798     Owner:  NLM     Status:  MEDLINE    
Injections of guanylyl-imido-diphosphate (250, 500 and 1,000 microgram/kg) into the lateral cerebral ventricle of the anaesthetized cat induced increases in blood pressure and heart rate while the intravenous injections of the same doses were ineffective, thus indicating a central mechanism of action of this compound which activates adenylcyclase at the catalytic subunit. The results support the hypothesis that the activity of cardiovascular centres depends on the prevailing concentration of cAMP. Intracerebroventricular injection of cGMP (125, 250 and 500 microgram/kg) caused hypotension and bradycardia. The effects increased with the dose but were subject to tachyphylaxis. The lack of an effect after intravenous administration indicates a central site of action. This result is in agreement with the Yin Yang hypothesis and suggests that cGMP is a second transmitter in cardiovascular centres which may be involved in central cardiovascular effects in response to stimulation by putative neurotransmitter substances such as acetylcholine.
P Schuhmacher; A Walland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  312     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Cyclic GMP / administration & dosage,  pharmacology*
Guanosine Triphosphate / analogs & derivatives*
Guanylyl Imidodiphosphate / administration & dosage,  pharmacology*
Heart Rate / drug effects
Injections, Intraventricular
Reg. No./Substance:
34273-04-6/Guanylyl Imidodiphosphate; 7665-99-8/Cyclic GMP; 86-01-1/Guanosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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